Electrochemical Behavior and Polarographic Determination of Auronofin

Méndez, J. Hernández; Pérez, A. Sánchez; Zamarreño, M. Delgado

doi:10.1002/jps.2600780717

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…13,14 Auranofin can undergo reduction to colloidal gold, the process being irreversible. Cyclic voltammetry studies show sufficiently high reduction potentials for auranofin, myocrisin, and the parent compounds so that all these compounds may be easily and quickly reduced by glutathione and other thiols within the cellular environment.…”

Section: B Gold(i) Compoundsmentioning

confidence: 99%

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

et al. 2009

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Gold compounds are a class of metallodrugs with great potential for cancer treatment. During the last two decades, a large variety of gold(I) and gold(III) compounds are reported to possess relevant antiproliferative properties in vitro against selected human tumor cell lines, qualifying themselves as excellent candidates for further pharmacological evaluation. The unique chemical properties of the gold center confer very interesting and innovative pharmacological profiles to gold-based metallodrugs. The primary goal of this review is to define the state of the art of preclinical studies on anticancer gold compounds, carried out either in vitro or in vivo. The available investigations of anticancer gold compounds are analyzed in detail, and particular attention is devoted to underlying molecular mechanisms. Notably, a few biophysical studies reveal that the interactions of cytotoxic gold compounds with DNA are generally far weaker than those of platinum drugs, implying the occurrence of a substantially different mode of action. A variety of alternative mechanisms were thus proposed, of which those involving either direct mitochondrial damage or proteasome inhibition or modulation of specific kinases are now highly credited. The overall perspectives on the development of gold compounds as effective anticancer drugs with an innovative mechanism of action are critically discussed on the basis of the available experimental evidence.

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Section: B Gold(i) Compoundsmentioning

confidence: 99%

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

et al. 2009

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The Electrochemistry of Gold and Silver Complexes

Mohamed

Bruce

2009

Patai's Chemistry of Functional Groups

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Introduction Dithiolenes and Diselenolenes Dithiocarbamates L 2 Au and L n Ag Complexes Phosphine Gold Halides Phosphine Gold Thiolates and Mixed Donor Ligands Phosphorus Ylides Organometallics Drugs Imides and Anilides Other Ligands and Structural Types

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