Electrochemical Behavior of Biologically Important Indole Derivatives

Abstract

Voltammetric techniques are most suitable to investigate the redox properties of a new drug. Use of electrochemistry is an important approach in drug discovery and research as well as quality control, drug stability, and determination of physiological activity. The indole nucleus is an essential element of a number of natural and synthetic products with significant biological activity. Indole derivatives are the well-known electroactive compounds that are readily oxidized at carbon-based electrodes, and thus analytical procedures, such as electrochemical detection and voltammetry, have been developed for the determination of biologically important indoles. This paper explains some of the relevant and recent achievements in the electrochemistry processes and parameters mainly related to biologically important indole derivatives in view of drug discovery and analysis.

Determination of sertindole in biological material by gas chromatography-mass spectrometry

“…Karaaslan із співавт. запропонували електрохімічний метод визначення сертиндолу у си-роватці та лікарських формах [11]. Запропонований метод, за даними авторів, може служити альтернати-вою методу рідинної хроматографії при моніторингу терапевтичних концентрацій сертиндолу.…”

Synthesis, characterization and electrochemical properties of some biologically important indole-based-sulfonamide derivatives

“…The electrochemical techniques have been effectively applied to study the redox properties of several biologically important compounds [20,21]. As reported previously, the redox behavior of indole derivatives was investigated using various electrodes: pyrolytic carbon [22], glassy carbon [17,23], platinum [24], lead dioxide [25] boron-doped diamond [26,27], and other electrodes [28][29][30]. Among the studied indole compounds with a substituent at C3, the results of electrochemical oxidation of indole-3-acetic acid, indole-3-propionic acid, indole-3-butyric acid, indol-3-acetamide, tryptamine, gramine and tryptophan were reported for the measurements done with the usage of a glassy carbon electrode as the working electrode [23,31].…”

Quantification of Cr(VI)-Thymoquinone Complex Using Cyclic Voltammetry

“…The use of electro analysis is increasing day by day due to high sensitivity, reduction in solvent and sample consumption, high-speed and low operating cost (Almeida et al, 2013;Halls et al, 2013;Yuzhi Li et al, 2013;Cheng et al, 2012;Aaboubi and Housni, 2012;Farghaly and Ghandour, 2005). Especially voltammetric techniques have proved to be more suitable to investigate the redox properties of drugs and biological analytes (Baghbamidi et al, 2012;Karaaslan and Suzen, 2011).…”