Electrochemical Behaviour of Tinidazole at 1,4-Benzoquinone Modified Carbon Paste Electrode and Its Direct Determination in Pharmaceutical Tablets and Urine by Differential Pulse Voltammetry

Abstract

A simple and highly sensitive electrochemical method based on a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE) was described for the determination of tinidazole (TDZ). In Britton Robinson buffer solution, TDZ yields well-defined irreversible reduction peak at −0.344 V on a 1,4-BQMCPE. Compared with that on a bare CPE, the reduction peak of TDZ increased significantly on the modified CPE and the effects of different parameters on the voltammetric responses were also investigated. Differential pulse voltammetric method was proposed and optimized for TDZ determination and its reductive peak current response at 1,4-BQMCPE was found to show linear dependence on the concentration of TDZ in the range of 1.0 × 10−6 to 5.0 × 10−4 M with a linear regression equation, correlation coefficient, limit of detection (LOD), and limit of quantification (LOQ) of IPC (μA) = 0.19958 + 0.02657C (μM), 0.99486, 1.10 × 10−7 M, and 3.77 × 10−7, respectively. Excellent recovery results for spiked TDZ in pharmaceutical tablet samples ranging within 97.44–97.51% and in urine ranging within 95.37–96.91% were observed. The selectivity of the method for TDZ was further studied in the presence of selected potential interferents and confirmed the potential applicability of the developed method for the determination of TDZ.

Voltammetric study of secnidazole and its determination in pharmaceutical tablet using 1, 4-benzoquinone modified carbon paste electrode

“…Table 3 indicated that most of the selected interferents did not significantly affect the peak current response for the SCZ which is comparable with a result reported somewhere (Elqudabyet al, 2013;Youssef et al, 2015). But metronidazole and tinidazole showed positive interference on the peak current for SCZ and this is because both metronidazole (Nikodimos and Amare, 2016) and tinidazole (Taye and Amare, 2016;Nikodimos and Hagos, 2017) contain the same reductive groups that can be reduced near the potentials of SCZ.…”

Nickel‐Based Metal‐Organic Framework/Crosslinked Tubular Poly(3,4‐ethylenedioxythiophene) Composite as an Electrocatalyst for the Detection of Gallic Acid and Tinidazole

“…[30] And common side effects of TNZ include dizziness, weakness, headache, nausea and upset stomach. [31][32][33][34][35] Although some electrochemical sensors have been developed to detect gallic acid and tinidazole, their linear range and sensitivity need to be improved. Therefore, it is essential to develop a novel electrocatalyst for efficient electrochemical detection of gallic acid and tinidazole, respectively.…”

“…For example, high concentration of gallic acid has certain cytotoxicity . And common side effects of TNZ include dizziness, weakness, headache, nausea and upset stomach . Although some electrochemical sensors have been developed to detect gallic acid and tinidazole, their linear range and sensitivity need to be improved.…”

Green versatile micellar electrokinetic chromatographic method for determination of six antimicrobial and anti-inflammatory drugs in combined dosage forms

“…The literature for SPI determination includes spectrophotometric [36], HPLC [37,38], UHPLC [39,40] and CE [41] methods. As for TNZ, the recent methods include spectrophotometry [42,43], electrochemical determination [44], TLC [45] and HPLC [46,47].…”