Electrochemical biosensing of cortisol in a hormone tablet and artificial bodily fluids

Olgaç, Nursel; Karakuş, Erman; Şahin, Yücel; Liv, Lokman

doi:10.1016/j.diamond.2022.109622

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…Thus, saturated current values were utilized as sensor signals. Significantly, the current signal increased from the introduction of 1 aM cortisol solution, which indicates the high sensitivity of our BP-FET biosensor compared with previously reported biosensors with the limit of detections only down to picomolar levels. ,, Presumably, BP nanofilms used in our experiments exhibited low noise levels and outstanding stabilities, resulting in the high performance of BP-FET sensors. Note that our sensor did not respond to the addition of a PBS buffer solution.…”

Section: Resultssupporting

confidence: 53%

Black Phosphorus-Based Reusable Biosensor Platforms for the Ultrasensitive Detection of Cortisol in Saliva

Lee,

Choi,

et al. 2024

ACS Appl. Mater. Interfaces

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A black phosphorus (BP)-based reusable biosensor platform is developed for the repeated and real-time detection of cortisol using antibody-conjugated magnetic particle (MP) structures as a refreshable receptor. Here, we took advantage of the lownoise characteristics of a mechanically exfoliated BP-based field-effect transistor (FET) and hybridized it with anti-cortisol antibodyfunctionalized MPs to build a highly sensitive cortisol sensor. This strategy allowed us to detect cortisol down to 1 aM in real time and discriminate cortisol from other hormones. In this case, we could easily remove MPs with used antibodies from the surface of a BP-FET and reuse the chip for up to eight repeated sensing operations. Moreover, since our platform could be fabricated using conventional photolithography techniques and the sensor can be reused multiple times, one should be able to significantly reduce operation costs for practical applications. Furthermore, this method could be utilized to detect different hormones with high sensitivity and selectivity in complex environments such as artificial saliva solutions. In this respect, our reusable BP-FET biosensing platform can be a powerful tool for versatile applications such as clinical diagnosis and basic biological analysis by conjugating various antibodies.

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Section: Resultssupporting

confidence: 53%

Black Phosphorus-Based Reusable Biosensor Platforms for the Ultrasensitive Detection of Cortisol in Saliva

Lee,

Choi,

et al. 2024

ACS Appl. Mater. Interfaces

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“…Cortisol is a steroid hormone in the human body that regulates blood sugar and promotes the breakdown of proteins and fats. Excessive cortisol secretion leads to conditions such as high blood pressure and osteoporosis [214,215].Lee et al [213] proposed an electrochemical sensor based on stretchable nanostructures to detect sweat cortisol, as shown in Figure 9d. Electrochemical impedance spectroscopy was utilized.…”

Section: Sweat Analysismentioning

confidence: 99%

Advanced Textile-Based Wearable Biosensors for Healthcare Monitoring

Li,

et al. 2023

Biosensors

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With the innovation of wearable technology and the rapid development of biosensors, wearable biosensors based on flexible textile materials have become a hot topic. Such textile-based wearable biosensors promote the development of health monitoring, motion detection and medical management, and they have become an important support tool for human healthcare monitoring. Textile-based wearable biosensors not only non-invasively monitor various physiological indicators of the human body in real time, but they also provide accurate feedback of individual health information. This review examines the recent research progress of fabric-based wearable biosensors. Moreover, materials, detection principles and fabrication methods for textile-based wearable biosensors are introduced. In addition, the applications of biosensors in monitoring vital signs and detecting body fluids are also presented. Finally, we also discuss several challenges faced by textile-based wearable biosensors and the direction of future development.

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Advances in electrochemical biosensor design for the detection of the stress biomarker cortisol

Weber,

Clay,

Lycan

et al. 2023

Anal Bioanal Chem

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Electrochemical biosensing of cortisol in a hormone tablet and artificial bodily fluids

Cited by 9 publications

References 43 publications

Black Phosphorus-Based Reusable Biosensor Platforms for the Ultrasensitive Detection of Cortisol in Saliva

Black Phosphorus-Based Reusable Biosensor Platforms for the Ultrasensitive Detection of Cortisol in Saliva

Advanced Textile-Based Wearable Biosensors for Healthcare Monitoring

Advances in electrochemical biosensor design for the detection of the stress biomarker cortisol

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