Electrochemical biosensor for the interaction of DNA with the alkylating agent 4,4′-dihydroxy chalcone based on guanine and adenine signals

Electrochemical behavior of 1-ferrocenyl-3-phenyl-2-propen-1-one on glassy carbon electrode and evaluation of its interaction parameters with DNA

“…3 In this regard, chalcones have been the subject of intensive investigations due to their strong intercalative interaction with DNA. 4,5 Chalcones are flavonoids that lack the C ring. The presence of a 4 -OH group and an a, b-unsaturated double bond are essential features for the cytotoxic activity of this class of compound.…”

Synthesis and voltammetric detection of 1H-benzimidazole derivatives on the interaction with DNA

“…Calf thymus ds and ssDNA's were immobilized onto DGE surfaces via adsorption (34). Accumulation of 1H-benzimdazole derivates were performed at DNA modified DGE surfaces with various concentrations of their solutions by applying open circuit mode for 5 minutes (27,28). Determination of interaction mechanisms of drugs's were obtained by applying DPV for transduction of benzimidazole derivates' electrochemical responses.…”

“…The DNA biosensor simply based on a recognition surface covered with DNA molecule, a signal transducer and amplifier that determines and amplifies the biological interaction between two DNA strands and a user interface that shows the data from interaction (27)(28)(29).…”

Comparative Studies of Quercetin Interactions with Monophosphate Nucleotides Using UV‐Vis Spectroscopy and Electrochemical Techniques

“…Kanakis et al reported that quercetin and other polyphenols bind weakly to adenine, guanine (major groove) and thymine (minor groove) bases as well as to the backbone phosphate groups present in calf-thymus DNA under physiological conditions [7]. Nucleophilic groups such as PO 4 3À and NH 3 present in nucleic acids have been reported to be the active sites for alkylating agents such as 4,4-dihydroxy chalcone [8]. Quercetin, isoliquiritigenin and butein with structural similarities to the chalcones have been reported to induce death of cancerous cells [9,10].…”

“…Quercetin, isoliquiritigenin and butein with structural similarities to the chalcones have been reported to induce death of cancerous cells [9,10]. Thus these molecules may exhibit similar alkylating properties on the nucleotides or polynucleotides respectively if carbonium ions are generated [8] and may ultimately be linked to quercetin cytotoxicity.…”