A probe for a screening evaluation test of quality and safety of foods based on four different amperometric biosensors all having Clark's electrode as transducer and different biological systems as components is described. Specifically three amperometric biosensors (tyrosinase, cyclooxygenase and superoxide dismutase biosensor) and a respirometric test are the components of the probe. For each proposed sensor robustness and LODs were evaluated. The latter ones for each analyte are compared with Maximum Residue Limits (MRLs) admitted in foods according to EEC Norm. Lastly, two different simple extraction procedures of the analytes to be detected from the food matrix have been planned and set up, in any case obtaining more than 70% extracted.