Electrochemical Characterization of New 1,5-Benzodiazepine Derivatives

Abstract

Cyclic voltammetry was used to study the electrochemical behavior of new 1,5-benzodiazepine derivatives on a glassy carbon electrode. Well-defined oxidation peaks were observed in DMSO. The Electrochemical response of the glassy carbon electrode was evaluated as function of the scan rate, showing that the electron transfer process for compound (5) and (6) resulted to be controlled by diffusion.

Electrochemical characterization of 1,5-benzodiazepine oximes in organic solvents

“…The influence of the square root of the voltage scan rate (w 1/2 ) on the oxidation peak current showed a linear relationship within the whole range studied (Fig. 5) and the slope varied in the interval 0.42-0.56, which is typical of a diffusion controlled oxidation process, and the corresponding value is presented in literature for 1,5-BZD derivatives [2]. Similar dependences were determined for all synthesized oximes in all solvents used.…”

“…Benzodiazepines (BZD) and their polycyclic derivatives are pharmacologically active compounds that have extensive applications in medicine as psychoactive drugs [1]. They are widely used as analgesics, hypnotics, sedatives and antidepressants as well as anti-inflammatory agents [1,2]. 1,4 and 1,5-BZD are reported to possess distinctive pharmacological effects.…”

“…Cyclic voltammograms were recorded for all the synthesized compounds in different solvents, at different pH values and varying the potential scan rate. Glassy carbon electrode was used as a working electrode due to its wide potential range, chemical inertness, impermeability to gases and extremely low porosity [2].…”