Electrochemical Chemically Based Sensors and Emerging Enzymatic Biosensors for Antidepressant Drug Detection: A Review

Abstract

Major depressive disorder is a widespread condition with antidepressants as the main pharmacological treatment. However, some patients experience concerning adverse reactions or have an inadequate response to treatment. Analytical chromatographic techniques, among other techniques, are valuable tools for investigating medication complications, including those associated with antidepressants. Nevertheless, there is a growing need to address the limitations associated with these techniques. In recent years, electrochemical (bio)sensors have garnered significant attention due to their lower cost, portability, and precision. Electrochemical (bio)sensors can be used for various applications related to depression, such as monitoring the levels of antidepressants in biological and in environmental samples. They can provide accurate and rapid results, which could facilitate personalized treatment and improve patient outcomes. This state-of-the-art literature review aims to explore the latest advancements in the electrochemical detection of antidepressants. The review focuses on two types of electrochemical sensors: Chemically modified sensors and enzyme-based biosensors. The referred papers are carefully categorized according to their respective sensor type. The review examines the differences between the two sensing methods, highlights their unique features and limitations, and provides an in-depth analysis of each sensor.

Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids

“…Kaur et al, (2022) [7] focused on electrochemical sensors using carbon-based nanomaterials for sensing drug and food pollutants. Most recently, Smith et al, (2023) [8] reviewed advances in the broad field of wearable sensing, while Calevilla et al, (2023) [9] reviewed work on sensors and biosensors applied to the monitoring of drugs for treating depression.…”

Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

“…Almost two centuries have passed since then, and today medicine is increasingly using protein drugs in a wide variety of areas of clinical practice [2]. Enzyme-based protein preparations are the most widely used in medicine [3] and cosmetology [4]. Enzymes are mainly used 1.…”