Electrochemical detection of dopamine with negligible interference from ascorbic and uric acid by means of reduced graphene oxide and metals-NPs based electrodes

Patella, Bernardo; Sortino, Alessia; Mazzara, Francesca; Aiello, Giuseppe; Drago, Giuseppe; Torino, Claudia; Vilasi, Antonio; O’Riordan, Alan; Inguanta, Rosalinda

doi:10.1016/j.aca.2021.339124

Cited by 63 publications

(19 citation statements)

References 89 publications

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“…In Figure 7D, the spectrum of rGO only is reported for comparison. In the Raman spectrum of rGO two main peaks at about 1350 and 1600 cm −1 , corresponding to the D and G band [118], respectively, can be observed. These peaks were found also in the rGO-ZnO-NRs electrode confirming the deposition of rGO.…”

Section: Resultsmentioning

confidence: 96%

Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor

et al. 2022

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Immunoglobulin G (IgG), a type of antibody, represents approximately 75% of serum antibodies in humans, and is the most common type of antibody found in blood circulation. Consequently, the development of simple, fast and reliable systems for IgG detection, which can be achieved using electrochemical sandwich-type immunosensors, is of considerable interest. In this study we have developed an immunosensor for human (H)-IgG using an inexpensive and very simple fabrication method based on ZnO nanorods (NRs) obtained through the electrodeposition of ZnO. The ZnO NRs were treated by electrodepositing a layer of reduced graphene oxide (rGO) to ensure an easy immobilization of the antibodies. On Indium Tin Oxide supported on Polyethylene Terephthalate/ZnO NRs/rGO substrate, the sandwich configuration of the immunosensor was built through different incubation steps, which were all optimized. The immunosensor is electrochemically active thanks to the presence of gold nanoparticles tagging the secondary antibody. The immunosensor was used to measure the current density of the hydrogen development reaction which is indirectly linked to the concentration of H-IgG. In this way the calibration curve was constructed obtaining a logarithmic linear range of 10–1000 ng/mL with a detection limit of few ng/mL and good sensitivity.

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Section: Resultsmentioning

confidence: 96%

Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor

et al. 2022

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“…As presented in Figure 10 a, there was about a 20% enhanced peak current response on GOQD over respective control SPCE, which may be due to negative charge carried with GOQD and enhanced electronic conductivity effects. Next, simultaneous electrochemical determination of uric acid (UA) and ascorbic acid (AA) were chosen as a model compound due to their importance in a biological system [ 45 , 46 ]. In general, owing to their closer electrochemical oxidation potentials, an overlapped electrochemical oxidation signal was observed while analyzing these compounds.…”

Section: Resultsmentioning

confidence: 99%

A Size-Controlled Graphene Oxide Materials Obtained by One-Step Electrochemical Exfoliation of Carbon Fiber Cloth for Applications to In Situ Gold Nanoparticle Formation and Electrochemical Sensors—A Preliminary Study

et al. 2022

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A simple, one-step and facile method has been introduced to prepare fluorescent and electrochemically active carbon nanoparticles with single-size distribution and good long-term stability by electrochemical exfoliation of polyacrylonitrile-based carbon fibers in an alkaline solution-phase condition. The preparation condition was systematically optimized by studying the effect of temperature and electrolytes. It has been found that an electrochemical exfoliation reaction carried out at an applied potential of 2 V vs. Ag/AgCl in a phosphate-ion-containing alkaline solution at a temperature of 40 °C is an ideal condition for the preparation of 14 ± 4 nm-sized carbon nanoparticles. Unlike the literature protocols, there are no filtration and membrane dialysis-based off-line sample pretreatments adopted in this work. The as-prepared carbon nanoparticles were characterized by fluorescence, Raman spectrum, transmission electron microscope, and X-ray photoelectron spectroscopic characterization methods. It was found that the carbon–oxygen functional group rich in graphene–oxide quantum dots (GOQDs) such as carbon nanoparticles were formed in this work. A preliminary study relating to simultaneous electrochemical oxidation and the sensing of uric acid and ascorbic acid with well-resolved peaks was demonstrated as a model system to extend the new carbon material for electroanalytical applications. Furthermore, in situ synthesis of 2 nm-sized gold nanoparticles stabilized by GOQDs was presented. The carbon nanoparticles prepared by the direct method in this work have shown good stability over 6 months when stored at room temperature. The electrochemical exfoliation reaction has been found to be highly reproducible and suitable for bulk synthesis of luminescence-effective carbon nanoparticles to facilitate fundamental studies and practical applications.

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“…UA produce a minimal response, and its outcome was insignificant. Patella et al [32] also reported a minor reaction for UA The amperometry approach (differential pulsed) constantly reacted, with a steady applied voltage, rising into the current with subsequent of 4 µM DA in the PBS electrolytic media, as illustrated in Figure 6b. With the addition of AA and UA under the optimized testing conditions as potentially interfering components, the AgNPs-2ADPA incorporated electrode showed good non-participation of AA and UA.…”

Section: Study Utilizing the Agnps-2adpa Doped Electrodementioning

confidence: 92%

“…UA produce a minimal response, and its outcome was insignificant. Patella et al [32] also reported a minor reaction for UA and AA in the DPV analyses since they produced around 12-and 6% responses. AgNPs-2ADPA was capable of enhancing the catalytic performance of DA.…”

Section: Study Utilizing the Agnps-2adpa Doped Electrodementioning

confidence: 94%

Role of Silver Nanoparticle-Doped 2-Aminodiphenylamine Polymeric Material in the Detection of Dopamine (DA) with Uric Acid Interference

et al. 2022

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A viable electrochemical approach for the detection of dopamine (DA) in uric acid (UA) utilizing a silver nanoparticle-doped 2-aminodiphenylamine (AgNPs-2ADPA) electrode was invented. The electrochemical performance of DA showed that the incorporated electrode displayed outstanding electrocatalytic performance to the electrochemical oxidation of DA. In our study, the AgNPs-2ADPA exhibits remarkable catalytic activity, retaining high current value and resilience when employed as a working electrode component for electrocatalytic detection of DA. We have also utilized the bare and polymeric-2ADPA in DA detection for a comparison study. This method offers a facile route with extraordinary sensitivity, selectivity, and strength for the voltammetric detection of DA, even in the presence of UA and ascorbic acid (AA) as interferents, that can be employed for pharmaceutical and biological specimens.

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Electrochemical detection of dopamine with negligible interference from ascorbic and uric acid by means of reduced graphene oxide and metals-NPs based electrodes

Cited by 63 publications

References 89 publications

Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor

Electrochemical Synthesis of Zinc Oxide Nanostructures on Flexible Substrate and Application as an Electrochemical Immunoglobulin-G Immunosensor

A Size-Controlled Graphene Oxide Materials Obtained by One-Step Electrochemical Exfoliation of Carbon Fiber Cloth for Applications to In Situ Gold Nanoparticle Formation and Electrochemical Sensors—A Preliminary Study

Role of Silver Nanoparticle-Doped 2-Aminodiphenylamine Polymeric Material in the Detection of Dopamine (DA) with Uric Acid Interference

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