2012
DOI: 10.1039/c2lc40650k
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Electrochemical detection of pyocyanin in nanochannels with integrated palladium hydride reference electrodes

Abstract: Miniaturized and integrated components for electrochemical detection in micro- and nano-fluidic devices are of great interest as they directly yield an electrical signal and promise sensitive, label-free, real-time detection. One of the challenges facing electrochemical sensing is the lack of reliable reference electrode options. This paper describes the fabrication and characterization of a microscale palladium hydride reference electrode in a single microfabrication step. The reference electrode was integrat… Show more

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Cited by 54 publications
(45 citation statements)
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“…11 A more modern approach is the use of polymerase chain reaction (PCR) schemes to increase the amount of pathogenic DNA or RNA present in a sample, which is then used for rapid identication. Several groups have identied P. aeruginosa in liquid cultures by detecting pyocyanin electrochemically, 16,[19][20][21][22] but this format is not typically employed by pathologists for analysis. 13,14 PCR-based approaches are much more selective and sensitive; however, they use expensive reagents and require specialized personnel or expensive instrumentation to handle the sample prep and data analysis.…”
Section: Introductionmentioning
confidence: 99%
“…11 A more modern approach is the use of polymerase chain reaction (PCR) schemes to increase the amount of pathogenic DNA or RNA present in a sample, which is then used for rapid identication. Several groups have identied P. aeruginosa in liquid cultures by detecting pyocyanin electrochemically, 16,[19][20][21][22] but this format is not typically employed by pathologists for analysis. 13,14 PCR-based approaches are much more selective and sensitive; however, they use expensive reagents and require specialized personnel or expensive instrumentation to handle the sample prep and data analysis.…”
Section: Introductionmentioning
confidence: 99%
“…The StapBot uses a nanosensor that scans for the presence of bacteria. This technology diameters of 10 mm that vibrate when it senses bacteria s tiniest metabolic movements [13]. The vibrations are then measured via a laser that reflects off the lever, turning them into an electrical current that can be read.…”
Section: ) Bacterial Targeting Biosensormentioning
confidence: 99%
“…In the past two decades, label-free alternatives have been studied by many authors. Some of the examples include quartz crystal microbalance (QCM), 1-3 surface acoustic wave (SAW) devices, 4,5 surface plasmon resonance (SPR), 6,7 silicon microcantilevers, [8][9][10][11] electrochemical sensors, [12][13][14] nanotube and nanowire biosensors. [15][16][17] Although these label-free methods can be rapid and simpler, they generally lack the sensitivity of ELISA.…”
Section: Introductionmentioning
confidence: 99%