Electrochemical detection of triamterene in human urine using boron-doped diamond electrodes

Ishii, Kanako; Ogata, Genki; Einaga, Yasuaki

doi:10.1016/j.bios.2022.114666

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…A Raman spectrum was obtained by an Acton SP2500 (Princeton Instruments) with a 532 nm laser (Figure S2) to confirm the successful fabrication of BDD . The surface morphology of the BDD electrode was recorded using a scanning electron microscope (JCM-6000, JEOL).…”

Section: Methodsmentioning

confidence: 99%

“…A Raman spectrum was obtained by an Acton SP2500 (Princeton Instruments) with a 532 nm laser (Figure S2) to confirm the successful fabrication of BDD. 37 The surface morphology of the BDD electrode was recorded using a scanning electron microscope (JCM-6000, JEOL). As shown in Figure S3, the grain sizes of the polycrystalline diamond were around 2−5 μm, which correspond well to our group's previous work.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Electrochemical Diagnosis of Urinary Tract Infection Using Boron-Doped Diamond Electrodes

Zhang,

Ogata,

Asai

et al. 2023

ACS Sens.

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Efficient detection of sodium nitrite in human urine could be used to diagnose urinary tract infections rapidly. Here, we demonstrate a fast and novel method for the selective detection of sodium nitrite in different human urine samples using electrolysis with a bare boron-doped diamond electrode. The measurement is performed without adding any other species, such as enzymes, and uses a simple electrochemical approach with an oxidation step followed by reduction. In the present study, we pay attention to the reduction potential range for the measurement, which is substantially different from many previous literature reports that focus on the oxidation reaction. The determination of added sodium nitrite based on cyclic voltammetry or differential pulse voltammetry is employed for two pooled urine samples and three individual urine matrices. From this, the linear response ranges for sodium nitrite detection are 0.5–10 mg/L (7.2–140 μmol/L) and 10–400 mg/L (140–5800 μmol/L). The results from these urine samples convert well to the calibration curve, with a limit of detection established as 0.82 mg/L (R 2 = 0.9914), which is clinically relevant.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Electrochemical Diagnosis of Urinary Tract Infection Using Boron-Doped Diamond Electrodes

Zhang,

Ogata,

Asai

et al. 2023

ACS Sens.

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“…As was the case for the studies reviewed on blood-based biofluids, the majority of studies reporting on electrochemical drug sensing in urine have relied heavily on processing to remove the protein content or sample dilution in order to mitigate interference effects. Only one study by Ishii et al demonstrated drug quantification in unprocessed urine [91]. In that work, the investigators used boron-doped diamond (BDD) electrodes to monitor the reduction of the diuretic triamterene.…”

Section: Detection Of Analyte Drugs In Urinementioning

confidence: 99%

“…In that work, the investigators used boron-doped diamond (BDD) electrodes to monitor the reduction of the diuretic triamterene. The rationale for the choice of the BDD electrode include its resistance to biofouling, its stability, and its relatively large potential window [91]. The choice to monitor the triamterene reduction was motivated by the occurrence of high background current at higher potentials.…”

Section: Detection Of Analyte Drugs In Urinementioning

confidence: 99%

Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids

Fu,

Khederlou,

Lefevre

et al. 2023

Chemosensors

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Electrochemical detection, with its advantages of being rapid, multi-time point, compatible with cost-effective fabrication methods, and having the potential for miniaturization and portability, has great promise for point-of-care drug monitoring. However, a continuing challenge concerns the robust and sensitive electrochemical detection of pharmaceutical analytes from biological fluids. These complex matrices, such as saliva, sweat, interstitial fluid, urine, and blood/serum, contain multiple components that can contribute to an increased background or reduced analyte signal. In this mini-review, we discuss progress on electrochemical sensing in complex biofluids. We first introduce the challenge of drug titration in the management of various health conditions and provide an overview of the motivation for improved therapeutic drug monitoring, including current limitations. We then review progress on pharmaceutical drug detection from these biofluids with a focus on sample preprocessing, electrode modification for signal amplification, and/or electrode passivation to minimize fouling. Finally, we highlight promising strategies that have enabled robust drug quantification for clinical relevance and that may be useful for field-use systems.

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“…We utilized BDD, which is characterized by a wide potential window, small background current, and high stability and biofouling resistance, as the electrode material. The multifunctional electrode material, BDD, has been used as a drug sensor recently. − Doxorubicin (DOX) (Figure S1(a)) hydrochloride, which is an anthracycline anticancer drug, was used as the target substance. DOX is used in treating various malignancies, such as breast and ovarian carcinomas and acute lymphoblastic leukemia .…”

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confidence: 99%

Designing Molecularly Imprinted Polymer-Modified Boron-Doped Diamond Electrodes for Highly Selective Electrochemical Drug Sensors

Ishii,

Ogata,

Yamamoto

et al. 2024

ACS Sens.

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Drug detection in biological solutions is essential in studying the pharmacokinetics of the body. Electrochemical detection is an accurate and rapid method, but measuring multiple drugs that react at similar potentials is challenging. Herein, we developed an electrochemical sensor using a boron-doped diamond (BDD) electrode modified with a molecularly imprinted polymer (MIP) to provide specificity in drug sensing. The MIP is a polymer material designed to recognize and capture template molecules, enabling the selective detection of target molecules. In this study, we selected the anticancer drug doxorubicin (DOX) as the template molecule. In the electrochemical measurements using an unmodified BDD, the DOX reduction was observed at approximately −0.5 V (vs Ag/AgCl). Other drugs, i.e., mitomycin C or clonazepam (CZP), also underwent a reduction reaction at a similar potential to that of DOX, when using the unmodified BDD, which rendered the accurate quantification of DOX in a mixture challenging. Similar measurements conducted in PBS using the MIP−BDD only resulted in a DOX reduction current, with no reduction reaction observed in the presence of mitomycin C and CZP. These results suggest that the MIP, whose template molecule is DOX, inhibits the reduction of other drugs on the electrode surface. Selective DOX measurement using the MIP−BDD was also possible in human plasma, and the respective limits of detection of DOX in PBS and human plasma were 32.10 and 16.61 nM. The MIP−BDD was durable for use in six repeated measurements, and MIP−BDD may be applicable as an electrochemical sensor for application in therapeutic drug monitoring.

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Electrochemical detection of triamterene in human urine using boron-doped diamond electrodes

Cited by 8 publications

References 34 publications

Electrochemical Diagnosis of Urinary Tract Infection Using Boron-Doped Diamond Electrodes

Electrochemical Diagnosis of Urinary Tract Infection Using Boron-Doped Diamond Electrodes

Progress on Electrochemical Sensing of Pharmaceutical Drugs in Complex Biofluids

Designing Molecularly Imprinted Polymer-Modified Boron-Doped Diamond Electrodes for Highly Selective Electrochemical Drug Sensors

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