Electrochemical Detection of Zeranol and Zearalenone Metabolic Analogs in Meats and Grains by Screen-Plated Carbon-Plated Disposable Electrodes

Hsieh, Ming-Kun; Chen, Huiru; Chang, Jen‐Lin; She, Wei-Shao; Chou, Chi-Chung

doi:10.4236/fns.2013.47a005

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Owing to difficulties in using the electrodes for field analysis in electrochemical methods, the development and application of single‐use electrodes are widely desirable. The important note is that disposable electrodes only once used therefore not being affected by the contaminated carryover problems .…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotube/polyurethane modified hollow fiber‐pencil graphite electrode for in situ concentration and electrochemical quantification of anticancer drugs Capecitabine and Erlotinib

Es’haghi

Moeinpour

2019

Engineering in Life Sciences

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A sensitive electrochemical sensor has been designed for in situ preconcentration and determination of anticancer drugs Capecitabine (CPT) and Erlotinib hydrochloride (ETHC) based on a pencil graphite electrode modified with multivalued carbon nanotube—polyurethane (MWCNT‐PUFIX) nanocomposite that was supported with a piece of polypropylene hollow fiber (HF‐PGE). The electrochemical behavior of CPT and ETHC on the MWCNT‐PUFIX/HF‐PGE modified electrode was investigated by differential pulse voltammetry (DPV) techniques and the obtained results confirmed its efficiency for sensing of CPT and ETHC. The synthesized nanocomposite was characterized by infrared spectroscopy and scanning electron microscope. After optimization of some effective parameters on the method efficiency including pH, nanocomposite amount, the type of organic solvent, scan rate and the effect of some additives, the mentioned sensor presented suitable results for determination of CPT and ETHC with the linear ranges from 7.70 to 142.00 μM and 0.11 to 23.50 μM and detection limits of 0.11 and 0.02 μM, respectively. Also, the fabricated sensor has shown good performance in analysis of CPT and ETHC in biological samples.

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Section: Introductionmentioning

confidence: 99%

Carbon nanotube/polyurethane modified hollow fiber‐pencil graphite electrode for in situ concentration and electrochemical quantification of anticancer drugs Capecitabine and Erlotinib

Es’haghi

Moeinpour

2019

Engineering in Life Sciences

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“…One study successfully measured hormone residues in these products, finding fractions of ppb residues in the liver, kidney, and muscle tissue of cattle implanted with E2 and TBA [88]. Most other studies examined beef tissue for residues of zeranol, and never found concentrations above quantitation limits [96,97]. One older study that lacked a clear description of its analytical methods looked at beef liver, kidney, and muscle tissue for a suite of hormones (E2, MGA, progesterone, TBA, testosterone, and zeranol) and found no measurable residues [98].…”

Section: Residue Determination Via Food Animal Feeding Studies and Rementioning

confidence: 99%

“…A smaller number of studies have attempted to characterize residues of synthetic hormones in beef products [88,[96][97][98]. One study successfully measured hormone residues in these products, finding fractions of ppb residues in the liver, kidney, and muscle tissue of cattle implanted with E2 and TBA [88].…”

Section: Residue Determination Via Food Animal Feeding Studies and Rementioning

confidence: 99%

Hormone Use in Food Animal Production: Assessing Potential Dietary Exposures and Breast Cancer Risk

Nachman

Smith

2015

Curr Envir Health Rpt

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In recent years, increasing attention has been paid to the role of hormones in breast cancer etiology, following reports that heightened levels of endogenous hormones and exposure to exogenous hormones and other endocrinedisrupting chemicals through food and the environment are associated with increased breast cancer risk. Seven hormone drugs (testosterone propionate, trenbolone acetate, estradiol, zeranol, progesterone, melengestrol acetate, and bovine somatotropin) are approved by the U.S. Food and Drug Administration for use in food animals. There is concern that these drugs or their biologically active metabolites may accumulate in edible tissues, potentially increasing the risk of exposure for consumers. To date, the potential for human exposure to residues of these compounds in animal products, as well as the risks that may result from this exposure, is poorly understood. In this paper, we discuss the existing scientific evidence examining the toxicological significance of exposure to hormones used in food animal production in relation to breast cancer risk. Through a discussion of U.S. federal regulatory programs and the primary literature, we interpret the state of surveillance for residues of hormone drugs in animal products and discuss trends in meat consumption in relation to the potential for hormone exposure. Given the lack of chronic bioassays of oral toxicity of the seven hormone compounds in the public literature and the limitations of existing residue surveillance programs, it is not currently possible to provide a quantitative characterization of risks that result from the use of hormonal drugs in food animal production, complicating our understanding of the role of dietary hormone exposure in the population burden of breast cancer.

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Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

Mosburg,

Li,

Helmes

et al. 2024

Drug Testing and Analysis

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Hormonal growth promotants (HGPs) are a class of pharmaceutical agents commonly administered to cattle in the United States to improve growth rates of the animal, alter behavior, or to improve the desired characteristics of retail cuts of meat. There is a concern that low residual concentrations of HGPs may remain in tissue after slaughter, and consumption of tissues containing these compounds may increase the risk of adverse health outcomes, including cancer. Sensitive and selective methods are necessary to assess exposure of HGPs by populations that consume meat products from animals that may have been administered HGPs. A liquid chromatography–tandem mass spectrometry method was developed and validated to detect the low‐level presence of HGPs including estradiol, testosterone, estradiol benzoate, melengestrol, melengestrol acetate, progesterone, testosterone propionate, trenbolone, trenbolone acetate, and α‐zearalanol in retail cuts of meat following a liquid–liquid extraction using a high pH solution with 30–50× less mass of meat required as compared to similar approaches. Good chromatographic performance and sensitivity was achieved utilizing ammonium fluoride as a mobile phase additive without the need for derivatization. Validation parameters including accuracy, precision, recovery, matrix effects, limits of detection, limits of quantitation, linear range, and stability were determined. The limits of detection ranged from 0.1 to 1.0 ng/g, depending on the compound, with adequate accuracy and precision without the need for extensive sample preparation approaches.

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Electrochemical Detection of Zeranol and Zearalenone Metabolic Analogs in Meats and Grains by Screen-Plated Carbon-Plated Disposable Electrodes

Cited by 6 publications

References 28 publications

Carbon nanotube/polyurethane modified hollow fiber‐pencil graphite electrode for in situ concentration and electrochemical quantification of anticancer drugs Capecitabine and Erlotinib

Carbon nanotube/polyurethane modified hollow fiber‐pencil graphite electrode for in situ concentration and electrochemical quantification of anticancer drugs Capecitabine and Erlotinib

Hormone Use in Food Animal Production: Assessing Potential Dietary Exposures and Breast Cancer Risk

Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

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