Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE

Abstract

An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry (DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate (ν), accumulation time (tacc), accumulation potential (Uacc) and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10−7–1.6×10−6 M with low detection (LOD) and quantification (LOQ) limits of 9.66±0.04 nM and 32.25±0.07 nM, respectively, were obtained under these optimized conditions.

Carbon Nanotube Modified Glassy Carbon Electrodes for on‐line and off‐line in vitro Therapeutic Equivalence Assessment of Paracetamol Tablets

“…As some other authors have reported, a variety of excipients including cellulose, starch, talc, titanium dioxide, sodium lauryl sulfate, lactose, among others, do not interfere with the electrochemical signal of different APIs using different carbon-based working electrodes, even at excipient concentrations ranging from 60 to 100 times higher than the API. [45][46][47][48][49] Likewise, for the electrochemical study of PAR from different authors, no excipient interference was observed. [50][51][52] Since the modified electrodes will be in a solution at 37…”

Integrated Glycosylation Patterns of Glycoproteins and DNA Methylation Landscapes in Mammalian Oogenesis and Preimplantation Embryo Development

“…Approximately 200 cells were used from each developmental stage to investigate the TET protein level by electrochemical techniques. Sample preparation, electrochemical measurement, and data analysis were performed as described in previous studies ( Ozcan et al, 2017 ; Pandit et al, 2017 ; Wang et al, 2017 ).…”

“…Previous studies reported that the TET protein family, which includes important enzymes of DNA demethylation, is regulated by O-glycosylation, and plays an important role in maintaining the stemness of stem cells (Zhang et al, 2014;Hahn et al, 2019;Ross and Bogdanovic, 2019;Yu et al, 2019). The dynamic protein levels of TET were investigated by electrochemical techniques because of their high sensitivity, low instrumentation cost, relatively shorter analysis times, and lack of tedious extraction procedures when compared with other analytical techniques (Pandit et al, 2017). The size and shape of the prepared PANI and AuNPs were examined by a scanning electron microscope.…”

“…Owing to the difficulty of accurately detecting TET protein level with a very small number of cells by conventional techniques, the dynamic patterns of TET in mammal oogenesis and preimplantation embryo development have not been analyzed. Fortunately, the development of electrochemical technology makes it possible to accurately measure TET protein content in a very small number of cells, because of its high sensitivity, low instrumentation cost, relatively shorter analysis time, and lack of tedious extraction procedures compared with other analytical techniques (Pandit et al, 2017).…”

Non-enzymatic Electrochemical Sensing of 3-Hydroxybutyric Acid by Incorporating Manganese Oxide Modified Electrode and Nitroprusside Electrolyte

“…In general, the pH value of detection solution has a great influence on both electrochemical performance of sensor and activity of biomolecules. 29,31,32 Moreover, electrochemical redox reaction is significantly influenced by proton concentration, thus variation of sample pH results in analytical response variations. In particular, the acidic solution can affect to reduction behavior of SNP as described above.…”