Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals

Gupta, Vinod K.; Jain, Rajeev; Agarwal, Shilpi; Mishra, Ritesh; Dwivedi, Ashish

doi:10.1016/j.ab.2010.11.024

Cited by 74 publications

(24 citation statements)

References 48 publications

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“…Up to now, several analytical methods have been applied to determination of them, which includes high performance liquid chromatography [3], fluorescence [4], chemiluminescence [5], spectrophotometry [6], gas chromatography/mass spectrometry [7], capillary electrochromatography [8], and electrochemical methods [9]. Among them, the electrochemical technique turns out to be an inexpensive and effective way and attracts more attention due to its advantages of fast response, cheap instrumentation, simple operation, timesaving, high sensitivity and excellent selectivity [10,11]. However, the oxidation and reduction of the dihydroxybenzene isomers, especially HQ and CC, usually overlap together, rendering them be hardly resolved by conventional electrodes.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical preparation of porous graphene and its electrochemical application in the simultaneous determination of hydroquinone, catechol, and resorcinol

Zhang

2015

Sensors and Actuators B: Chemical

132

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Section: Introductionmentioning

confidence: 99%

Electrochemical preparation of porous graphene and its electrochemical application in the simultaneous determination of hydroquinone, catechol, and resorcinol

Zhang

2015

Sensors and Actuators B: Chemical

132

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“…The voltammogram of RB5 dye in BRB solution at pH 2.5 is shown in Figure 5. The E p of RB5 dye peak shifted to more negative potentials as the pH of BRB solution increased, indicating the involvement of H + in the reduction process of RB5 dye [36]. …”

Section: Results and Discussion Electrochemical Behaviour Of The Rb5 Dyementioning

confidence: 96%

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Yaacob¹

2016

MJAS

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A cyclic voltammetry (CV) and differential pulse cathodic stripping voltammetry (DPCSV) studies of RB5 in Britton-Robinson buffer (BRB) at a hanging mercury dropping electrode (HMDE) are described. CV was carried out by cathodic and anodic potential scan over the range of +200 mV to -800 mV with no accumulation time and three well-defined pH-dependent cathodic peaks were observed. The effects of different scan rates, pH of BRB, repetitive cycle and increasing concentrations on the peak height and peak potential of the analyte were studied. The results showed that RB5 dye was adsorbed and irreversibly reduced at the mercury electrode, mainly under diffusion controlled in the optimum pH 4.0 of BRB. By using DPCSV, pH of BRB and various instrumental parameters such as scan rate, accumulation time, accumulation potential and pulse amplitude that may affect the peak height of RB5 were investigated and optimized for RB5 determination. Under the optimized parameters, the peak height was found to be linear with RB5 concentration in the range from 2.5 x 10 -7 mol L -1 to 2.0 x 10 -6 mol L -1 . A detection limit (3SD/m) of 1.3 x 10 -8 mol L -1 was achieved. The precision of the developed method in terms of RSD was 0.55% for intra-day measurement and 0.55%, 0.24% and 0.40%, for inter-day measurements, respectively. The developed method was successfully applied in the determination of RB5 in batik wastewaters with the mean recovery of 83.97 ± 4.78% to 97.93 ± 5.45% (0.5 x 10 -6 mol L -1 ), 95.91 ± 2.68% to 103.49 ± 1.32% (1.0 x 10 -6 mol L -1 ) and 99.17 ± 0.75% to 105.12 ± 0.28% (2.0 x 10 -6 mol L -1 ). The developed method is considered sensitive, precise, accurate, rugged, robust, fast and low cost for routine analysis of RB5 dye in batik wastewaters over the UV-VIS spectrometry method.Keywords: Reactive Black 5, differential pulse cathodic stripping, Britton-Robinson buffer, hanging mercury dropping electrode, batik wastewater samples Abstrak Kajian voltammetri berkitar (CV) dan voltammetri perlucutan denyut kebezaan (DPCSV) terhadap pewarna RB5 dalam larutan penimbal Britton-Robinson (BRB) menggunakan elektrod jatuhan raksa tergantung (HMDE) dihuraikan. CV dijalankan dengan mengimbas potential kathodik dan anodik dari +200 mV ke -800 mV tanpa masa pengumpulan dan tiga puncak diperhatikan selepas imbasan. Kesan perbezaan kadar imbasan, pH BRB, imbasan berkitar yang berulang dan peningkatan kepekatan RB5 ke atas ketinggian dan nilai keupayaan puncak dikaji. RB5 yang dijerap dan diturunkan secara tidak berbalik pada permukaan elektrod merkuri adalah dibawah kawalan difusi pada pH BRB yang optimum iaitu 4.0. Dengan menggunakan DPCSV, pH BRB dan parameter-parameter peralatan yang memberi kesan kepada ketinggian puncak seperti kadar imbasan, masa pengumpulan, keupayaan pengumpulan dan amplitud denyut telah dioptimumkan untuk analisis RB5. Ketinggian puncak berkadar terus dengan kepekatan RB5 dalam julat dari 2.5 x 10 -7 mol L -1 hingga 2.0 x 10 -6 mol L -1 . Had pengesanan adalah 1.3 x 10 -8 mol L -1 . Ketepatan (RSD...

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“…The studied drugs have common biphenyl tetrazole nucleus [12,13]; as a result, they have the same spectral characters so these methods have no sufficient selectivity and cannot distinguish between them. Several electrochemical methods were reported for their quantification [14][15][16][17]. Different separation techniques such as electrophoresis [18][19] and high-performance liquid chromatography (HPLC) [20][21][22][23][24] were reported for the separation and determination of several members of the studied drugs.…”

Section: Introductionmentioning

confidence: 99%

Application of high-performance thin-layer chromatography for screening and simultaneous determination of some angiotensin II receptor antagonists in dosage forms and plasma

Hussein¹,

El-Wadood²,

Abdallah³

et al. 2014

Journal of Planar Chromatography – Modern TLC

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A high-performance thin-layer chromatographic (HPTLC) method was performed for simultaneous quantification of four angiotensin II receptor antagonists, namely, losartan, irbesartan, valsartan, and olmesartan. The method based on HPTLC separation of the four drugs using reflectance-absorbance mode at 255 nm. Separation was carried out on pre-coated silica gel HPTLC plates, using chloroform-glacial acetic acid (

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Electrochemical determination of antihypertensive drug irbesartan in pharmaceuticals

Cited by 74 publications

References 48 publications

Electrochemical preparation of porous graphene and its electrochemical application in the simultaneous determination of hydroquinone, catechol, and resorcinol

Electrochemical preparation of porous graphene and its electrochemical application in the simultaneous determination of hydroquinone, catechol, and resorcinol

Voltammetric Determination of Reactive Black 5 (Rb5) in Waste Water Samples From the Batik Industry

Application of high-performance thin-layer chromatography for screening and simultaneous determination of some angiotensin II receptor antagonists in dosage forms and plasma

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