Electrochemical determination of lead in human blood serum and urine by anodic stripping voltammetry using glassy carbon electrodes covered with Ag–Hg and Ag–Bi bimetallic nanoparticles

Valera, Danny; Sánchez, Mireya; Domínguez, José Ramón; Alvarado, José; Espinoza-Montero, Patricio J.; Carrera, Patricio; Bonilla, Pablo; Manciati, Carla; González, Gema; Fernández, Lenys

doi:10.1039/c8ay01314d

Cited by 22 publications

(20 citation statements)

References 32 publications

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“…Modified method according (Valera et al, 2018). Professional nurses collected blood samples directly into new "Vacutainer" tubes containing EDTA as an anticoagulant.…”

Section: Sample Recollection and Treatment 241 Bloodmentioning

confidence: 99%

“…Modified method according (Valera et al, 2018). Urine samples were collected by donors in virgin urine collection vessels.…”

Section: Urinementioning

confidence: 99%

“…To go further on diminishing toxicity, bismuth, a more ecologic element, was chosen instead of mercury as modifier for the sensor (Pei et al, 2014;Borgo et al, 2015). Based on those findings we have tried several glassy carbon (GC) modified electrodes for determination of Cd(II) and Pb(II) in human serum and urine samples (Valera et al,2018). In the present work we report on the determination of Cd and Pb in human serum and urine samples using two types of electrodes consisting one of them of a GC electrode covered by a Nafion (Nf) film doped with HgAg alloyed and by BiAg alloyed the second one.…”

Section: Introductionmentioning

confidence: 99%

“…Results y Discussion Figure 1a shows a micrograph of the Nf film covering the GC electrode (Valera et al,2018), which is the first step in the preparation of the modified, Nf/GC, electrode. In the figure, the whole Nf film seems to be flat presenting some holes, approximately 900 to 950 nm in diameter, seen as dark spots.…”

mentioning

confidence: 99%

“…In the figure, the whole Nf film seems to be flat presenting some holes, approximately 900 to 950 nm in diameter, seen as dark spots. Figure 1b shows a micrograph of the surface of the resulting AgBiNf/GC electrode, obtained after 180 min (Valera et al,2018). Immersion of the Nf covered GC electrode in a 0.85 µg L -1 Ag + 0.15 µg L -1 Bi solution.…”

mentioning

confidence: 99%

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Detection of Cd (II) and Pb (II) by anodic stripping voltammetry using glassy carbon electrodes modified with Ag-Hg and Ag-Bi bimetallic alloyed

Valera¹,

Sánchez

Domínguez³

et al. 2019

NOVASINERGIA

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Presentamos la evaluación de los electrodos de carbono vítreo (GC) modificados con películas de Nafion (Nf) y depósitos bimetálicos de aleaciones Ag-Hg y Ag-Bi. La mayoría de los bimetálicos depositados, con un tamaño promedio de aproximadamente 150 nm, se dispersaron e incrustaron uniformemente dentro de la red del Nafion, mientras que una cantidad mucho menor permaneció encima de las incrustadas sin ninguna orientación regular, como lo indica imágenes de microscopía electrónica de barrido (SEM) y microscopía de fuerza atómica (AFM). Las pruebas de sensibilidad para el electrodo modificado AgBiNf/GC produjeron límites de detección (DL), basados en la variabilidad de una solución en blanco (criterio de 3 s), de 0,78 y 0,66 μg L-1 para Cd (II) y Pb (II), respectivamente; mientras que el DL sobre el electrodo modificado AgHgNf/GC fue 0,17 y 0,24 μg L-1 para Cd (II) y Pb (II), respectivamente. La precisión de la metodología por voltametría de redisolución anódica se verificó mediante el cálculo de porcentajes de recuperación de los dos analitos, expresados como error relativo. Se logró una recuperación del 99% al 92%.

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“…Modified method according (Valera et al, 2018). Professional nurses collected blood samples directly into new "Vacutainer" tubes containing EDTA as an anticoagulant.…”

Section: Sample Recollection and Treatment 241 Bloodmentioning

confidence: 99%

“…Modified method according (Valera et al, 2018). Urine samples were collected by donors in virgin urine collection vessels.…”

Section: Urinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Detection of Cd (II) and Pb (II) by anodic stripping voltammetry using glassy carbon electrodes modified with Ag-Hg and Ag-Bi bimetallic alloyed

Valera¹,

Sánchez

Domínguez³

et al. 2019

NOVASINERGIA

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Electrochemical sensing of heavy metals in biological media: A review

Gonzalez,

Kazemeini,

Weber

et al. 2023

Electroanalysis

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Trace metals are required in the body as they play a significant role in several biochemical processes. Moreover, certain heavy metals are beneficial at appropriate levels. Copper (Cu), for example, is essential for red blood cell formation, bone strength, and infant growth. Despite these fundamental roles, Cu can become toxic at high levels. Other heavy metals such as lead (Pb), cadmium (Cd), manganese (Mn), and mercury (Hg), have been identified to cause acute and chronic health complications. For these reasons, rapid, real‐time quantification of such metals in biological media is of interest to improving human health outcomes. Electrochemical methods offer numerous advantages, such as portability, capability to be miniaturized, low cost, and ease‐of‐use. In this review, we examine recent developments in electrochemical sensing for the detection of heavy metals in biological media. To meet the requirements for inclusion in this review, the electrochemical sensor must have been evaluated in biological media (blood, serum, sweat, saliva, urine, brain tissue/cells). Several applications are explored to examine recent advancements in electrochemical sensing within these matrices. Addressing the challenges through materials, device, and system innovations, it is expected that electrochemical sensing of heavy metals in biological media will facilitate future diagnoses and treatments in healthcare.

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Contemporary electrochemical sensing and affinity biosensing to assist traces metal ions determination in clinical samples

Campuzano

Pedrero

Yáñez‐Sedeño

et al. 2021

Electrochemical Science Adv

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The determination of metals in clinical samples is an important challenge since their levels are relevant to ensure personal exposure to safe environments, as well as to assist in the prevention and treatment of disease. The low concentrations of metal ions in clinical samples and their coexistence with other metals and/or molecules of diverse nature implies the need for sensitive and selective analytical methodologies, which can be provided by conventional techniques. However, most of these techniques do not satisfy other highly demanded requirements such as high sampling frequency, multiplexed ability, and in-field analysis. In this context, the simplicity, speed of response, and compatibility with single or multiplexed point-of-care determinations have led to the successful incursion of electrochemical (bio)sensing into the clinical field for the determination of these analytes. Electrochemical (bio)devices have come on strong by exploiting and combining the unique attributes provided by electrochemical techniques (primarily voltammetry but also giving way to impedimetry in electrochemical affinity biosensing), electrode materials (Hg, Bi, Sb, Au, GCE, CPE, ITO, FTO), and substrates (conventional, screen-printed, flexible, paper, wearable or tattoo-type), suitable modifiers (nanomaterials, polymers, mesoporous films), bioreceptors (aptamers, peptides, biomolecular switches, DNAzymes, and DNA molecules), and nucleic acid amplification strategies (rolling circle and exonucleases-assisted target recycling). Therefore, the purpose of this review is to provide a bird's eye view of the state of the art, discussing the remarkable opportunities and potentialities demonstrated in the last decade by electrochemical sensors and electrochemical affinity biosensors for the analysis of metal ions in challenging clinical samples and forecasting future directions in this exciting field.

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Electrochemical determination of lead in human blood serum and urine by anodic stripping voltammetry using glassy carbon electrodes covered with Ag–Hg and Ag–Bi bimetallic nanoparticles

Abstract: The evaluation and application of glassy carbon electrodes modified with bimetallic nanoparticle deposits.

Cited by 22 publications

References 32 publications

Detection of Cd (II) and Pb (II) by anodic stripping voltammetry using glassy carbon electrodes modified with Ag-Hg and Ag-Bi bimetallic alloyed

Detection of Cd (II) and Pb (II) by anodic stripping voltammetry using glassy carbon electrodes modified with Ag-Hg and Ag-Bi bimetallic alloyed

Electrochemical sensing of heavy metals in biological media: A review

Contemporary electrochemical sensing and affinity biosensing to assist traces metal ions determination in clinical samples

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