Electrochemical determination of Saxagliptin hydrochloride with MWCNTs/CuO/4′aminobenzo-18-crown-6-ether composite modified carbon paste electrode

Abdallah, Nehad A.; Ibrahim, Heba

doi:10.1016/j.microc.2019.03.060

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…By comparing this work with others previously reported techniques in literature, including potentiometric sensor [19], Chromatographic [10], spectrophotometric [82] and fluorescence detection [81], as illustrated in Table 3, it is clear that MIP/MwCNT modified CPE sensor has a much lower LOD, higher sensitivity for Saxa, taking into consideration that, this is the first analysis technique relaying on molecular imprinted technology, which is advantageous for its selective recognition ability for its target analyte.…”

Section: Repeatability and Reproducibility Of The Sensormentioning

confidence: 67%

“…Different techniques were reported in literature for determination of Saxa, including: liquid chromatography with tandem mass detection [6] [7,8], HPLC [9][10][11][12][13][14][15], HPLC with fluorescence detection [16], HPTLC [17], spectrophotometric and fluorometric detection [18]. A potentiometric method was also reported based on carbon paste electrode (CPE) modified with MwCNTs-CuO aminobenzo-18-crown-6-ether composite [19]. To the best of our knowledge, there is no reported method in literature that involves the use of molecularly imprinted polymers (MIPs) for the electrochemical detection of Saxa.…”

Section: Introductionmentioning

confidence: 99%

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Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

et al. 2023

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Saxagliptin (Saxa) belongs to a new generation of antidiabetic pharmaceutical compounds used in combination with healthy diet and exercise to lower blood glucose levels in patients with type 2 diabetes mellitus (T2DM). In this work, we report for the first time a molecularly imprinted polymer (MIP) based electrochemical sensor for the determination of Saxa. Computational calculations were performed, based on which five MIPs were synthesized using Saxa as a template, itaconic acid as a monomer, crosslinked with ethylene glycol dimethacrylate and Di methyl sulfoxide (DMSO) as a porogen with different ratios. Non‐covalent interaction (NCI) analysis has been also conducted, and the obtained isosurface analysis was used for graphical visualization of NCI that could occur in real space as well as for the discrimination between hydrogen bond interaction, Van Der Waals attraction and spatial repulsion. The optimized polymer was incorporated as a modifier for designing an electrochemical sensor comprising MIP and Multiwalled carbon nanotubes (MwCNT) within carbon paste electrode (CPE). The operational variables including incubation time, pH, scan rate, and accumulation time were optimized. The sensor showed linearity over the concentration range (1 × 10−9–1 × 10−15 M) with low limit of detection (LOD) 8 × 10−16 and 2 × 10−16 M on using DPV and EIS, respectively. The sensor was successfully applied for pharmaceutical formulations, urine, and human serum samples with recovery range between 97.45–100.64 %.

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Section: Repeatability and Reproducibility Of The Sensormentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

et al. 2023

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“…[22][23][24][25][26][27] some electrochemical methods are also reported for determination of Metformin and Saxagliptin. [28][29][30] A stability-indicating method identify and estimates the analytes specifically with good resolution with its degradants in forced degradation study. As per ICH guidelines it's a prerequisite of development of stability-indicating method.…”

Section: Saxagliptinmentioning

confidence: 99%

Development and Validation of Novel Stability- Indicating LC Method for the Determination of Saxagliptin and Metformin

Gurav¹,

Bhatia²

2020

IJPER

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Aim: Development of a novel precise, selective and sensitive stability indicating RP-HPLC method has been developed and validated for the determination of Saxagliptin hydrochloride (SAX) and Metformin HCl (MET) in bulk drug and pharmaceutical dosage form. Materials and Methods: The separation was carried out on a Phenomenex Luna, SCX, 250 x 4.6mm, 10 µm using a mobile phase of ammonium dihydrogen phosphate buffer pH 2.50: methanol [70:30 % v/v]. Quantitation was achieved using UV detection at 210 nm. Results: The retention times were about 6.2 min for SAX and about 10.4min for MET. Calibration curves were linear over the concentration range from 5-100µg/mL for SAX and 40-800µg/mL for MET. Peak purity of SAX and MET established in presence of all major degradation product in stressed samples. Conclusion: The proposed method of analysis has been validated as per ICH guidelines and proved to be specific, precise, linear, rugged and robust. The effectiveness of the method was demonstrated with marketed pharmaceutical preparation of SAX and MET.

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“…On the other hand, various carbon-based materials (particularly carbon nanotubes and graphene) have received a great deal of attention in the past decades in electroanalysis owing to their large specic surface area, excellent conductivity and high chemical stability. [15][16][17][18][19] Nevertheless, their preparation procedures are very tough. Another carbonaceous material consisting of amorphous/quasi-graphitic primary particles, carbon black (CB), has gained increasing attention and emphasis by researchers recently, 20,21 and it boasts numerous interesting chemical/physical superiorities, such as large supercial area, excellent conductivity and chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive determination of anesthetic drug benzocaine based on hydroxypropyl-β-cyclodextrin–carbon black nanohybrids

Wang

Huang

et al. 2022

Anal. Methods

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Electrochemical determination of Saxagliptin hydrochloride with MWCNTs/CuO/4′aminobenzo-18-crown-6-ether composite modified carbon paste electrode

Cited by 17 publications

References 26 publications

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin

Development and Validation of Novel Stability- Indicating LC Method for the Determination of Saxagliptin and Metformin

Highly sensitive determination of anesthetic drug benzocaine based on hydroxypropyl-β-cyclodextrin–carbon black nanohybrids

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