Electrochemical electrophilic bromination/spirocyclization of N-benzyl-acrylamides to brominated 2-azaspiro[4.5]decanes

Abstract

An electrochemical electrophilic bromination/spirocyclization of N-benzyl-acrylamides with 2-bromoethan-1-ol as the brominating reagent has been developed. The paired electrolysis employs low concentrations of bromine produced from both cathodic reduction and anodic...

Probing the physical properties for prospective high energy applications of QMnF3 (Q = Ga, In) halide perovskites compounds employing the framework of density functional theory

“…This analysis aimed to determine the bonding nature of the compounds as well. 10–13 By employing GGA (generalized gradient approximation) and GGA + U methods, researchers analyzed the optical properties of several systems including rare earth. 14–17 It was found that the TB-mBJ approximation of the TB-mBJ potential is better suited for systems lacking correlated electrons, such as insulators and semiconductors.…”

Visible Light Promoted Brominative Dearomatization of Biaryl Ynones to Spirocycles

“…Inspired by the primary results of this photocatalytic oxidation of biaryl ynones, we next took the challenge of implementation of this strategy to other ynone systems ( 4 ) . Biphenyl N -arylpropiolamides are susceptible to exhibit synthetic versatility in radical chemistry and theoretically capable to undergo [1,1], [1,2], [1,5], and [2,5] cyclizations; some of the possibilities are designed in Figure and details in Supporting Information.…”

Electrophilic Halospirocyclization of N-Benzylacrylamides to Access 4-Halomethyl-2-azaspiro[4.5]decanes

“…7, 172.1, 147.2, 146.3, 132.8, 130.5, 64.0, 52.7, 49.1, 25.5, 24.9, 24.5, 24.3, 13.6 . 14 The title compound was prepared according to the general procedure and obtained as a white solid (41 mg, yield: 63%. ); 1 H NMR (400 MHz, CDCl 3 ) δ 7.10 (dd, J = 10.3, 3.0 Hz,1H),6.91 (dd,J = 10.3,3.0 Hz,1H),6.46 (dd,J = 10.3,1.9 Hz,1H),6.39 (dd,J = 10.3,1.9 Hz,1H),3H), 3.37 (d,J = 10.4 Hz,1H), 1.43 (s, 9H), 1.32 (s, 3H); 13 C{ 1 H} NMR (101 MHz, CDCl 3 ) δ 184.…”