Electrochemical immunosensor AuNPs/NG-PANI/ITO-PET for the determination of BDNF in depressed mice serum

Depression is a severe mental disorder which faces a challengeable lack of objective diagnosis as well as early screening and predicting treatment responses. Consequently, developing sensitive, efficient, convenient, accurate, and real-time detection technology for depression markers deserves more attention. Electrochemical immunosensors, as a promising method for analyzing disease markers, selectively bind the target antigen with antibodies, converting the biological signal of the antigen-antibody recognition reaction into an electrical signal related to the concentration of the target analyte. This method has thrived in recent years in areas such as point-of-care diagnosis. Here we systematically review the construction of electrochemical immunosensors for the detection of biomarkers of depression over a recent six year period (2016-2022), including the classification of these sensors, commonly used electrode modification materials, and signal optimization strategies. Finally, the challenges and future development of electrochemical immunosensors in clinical applications are prospected.

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Electrochemical immunosensor AuNPs/NG-PANI/ITO-PET for the determination of BDNF in depressed mice serum

Cited by 3 publications

References 45 publications

Visual dual-mode aptasensor for non-small cell lung cancer exosome detection via HRP self-coupling enhanced oxidized iridium nanoparticle aggregation

Visual dual-mode aptasensor for non-small cell lung cancer exosome detection via HRP self-coupling enhanced oxidized iridium nanoparticle aggregation

Electrochemical biosensors for depression: Diagnosis and therapeutic monitoring

Review—Electrochemical Immunosensors for Depression Markers Detection: Development in Recent Years

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