Electrochemical immunosensor based on MoS2 NFs/Au@AgPt YNCs as signal amplification label for sensitive detection of CEA

Ma, Enhui; Wang, Ping; Yang, Qingshan; Yu, Haoxuan; Pei, Fubin; Li, Yueyun; Liu, Qing; Dong, Yunhui

doi:10.1016/j.bios.2019.111580

Cited by 81 publications

(26 citation statements)

References 41 publications

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“…The biosensor had a range of linearity from 1 pg/mL to 50 ng/mL and a limit of detection of 0.27 pg/mL. Analogously, Ma et al [ 93 ] also synthesized a sandwich-type electrochemical immunosensor with a broader detecting range (10 fg/mL to 100 ng/mL) and a lower limit of detection (3.09 fg/mL). The trimetallic yolk-shell Au@AgPt nanocubes (Au@AgPt YNCs) with good catalytic activity loaded on amino-modified MoS 2 nanoflowers to form MoS 2 NFs/Au@AgPt YNCs as the marker of Ab 2 , which could catalyze the reduction of H 2 O 2 more effectively and thus amplify the current signal.…”

Section: Biosensorsmentioning

confidence: 99%

MoS2-based nanocomposites for cancer diagnosis and therapy

Wang

Li-hua

Huang

et al. 2021

Bioactive Materials

148

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Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used in biomedical research. Especially, MoS 2 -nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties. MoS 2 can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area, improving its tumor targeting and colloidal stability, as well as accuracy and sensitivity for detecting specific biomarkers. At the same time, in the near-infrared (NIR) window, MoS 2 has excellent optical absorption and prominent photothermal conversion efficiency, which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release. Significantly, the modified MoS 2 -nanocomposite can specifically respond to the tumor microenvironment, leading to drug accumulation in the tumor site increased, reducing its side effects on non-cancerous tissues, and improved therapeutic effect. In this review, we introduced the latest developments of MoS 2 -nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy. Furthermore, we also discuss the current challenges and prospects of MoS 2 -nanocomposites in cancer treatment.

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Section: Biosensorsmentioning

confidence: 99%

MoS2-based nanocomposites for cancer diagnosis and therapy

Wang

Li-hua

Huang

et al. 2021

Bioactive Materials

148

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“…Therefore, the sensor got a low detection limit of 26 fg mL −1 with the help of signal probe amplification. Other MoS 2 -based electrochemical nanoprobes were also used to detect cardiac troponin I, HBsAg, and CEA due to their outstanding signal amplification effect, respectively [ 49 , 50 , 74 ].…”

Section: Mos 2 -Based Nanoprobes For Sensing Appli...mentioning

confidence: 99%

Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

et al. 2022

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The use of nanoprobes in sensors is a popular way to amplify their analytical performance. Coupled with two-dimensional nanomaterials, nanoprobes have been widely used to construct fluorescence, electrochemical, electrochemiluminescence (ECL), colorimetric, surface enhanced Raman scattering (SERS) and surface plasmon resonance (SPR) sensors for target molecules’ detection due to their extraordinary signal amplification effect. The MoS2 nanosheet is an emerging layered nanomaterial with excellent chemical and physical properties, which has been considered as an ideal supporting substrate to design nanoprobes for the construction of sensors. Herein, the development and application of molybdenum disulfide (MoS2)-based nanoprobes is reviewed. First, the preparation principle of MoS2-based nanoprobes was introduced. Second, the sensing application of MoS2-based nanoprobes was summarized. Finally, the prospect and challenge of MoS2-based nanoprobes in future were discussed.

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“…The biosensor showed a sensitivity of 13.80 µA mM −1 cm −2 . The developed bio-catalytic interface based on two-dimensional MoS 2 and gold nanoparticles has the potential to be used for the immobilization of other biomolecules [49][50][51][52].…”

Section: Gold Nanostructures and Their Use In Hybrid Glucose Biosensorsmentioning

confidence: 99%

A Critical Review of Electrochemical Glucose Sensing: Evolution of Biosensor Platforms Based on Advanced Nanosystems

Juska

Pemble

2020

Sensors

147

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The research field of glucose biosensing has shown remarkable growth and development since the first reported enzyme electrode in 1962. Extensive research on various immobilization methods and the improvement of electron transfer efficiency between the enzyme and the electrode have led to the development of various sensing platforms that have been constantly evolving with the invention of advanced nanostructures and their nano-composites. Examples of such nanomaterials or composites include gold nanoparticles, carbon nanotubes, carbon/graphene quantum dots and chitosan hydrogel composites, all of which have been exploited due to their contributions as components of a biosensor either for improving the immobilization process or for their electrocatalytic activity towards glucose. This review aims to summarize the evolution of the biosensing aspect of these glucose sensors in terms of the various generations and recent trends based on the use of applied nanostructures for glucose detection in the presence and absence of the enzyme. We describe the history of these biosensors based on commercialized systems, improvements in the understanding of the surface science for enhanced electron transfer, the various sensing platforms developed in the presence of the nanomaterials and their performances.

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Electrochemical immunosensor based on MoS2 NFs/Au@AgPt YNCs as signal amplification label for sensitive detection of CEA

Cited by 81 publications

References 41 publications

MoS2-based nanocomposites for cancer diagnosis and therapy

MoS2-based nanocomposites for cancer diagnosis and therapy

Molybdenum Disulfide-Based Nanoprobes: Preparation and Sensing Application

A Critical Review of Electrochemical Glucose Sensing: Evolution of Biosensor Platforms Based on Advanced Nanosystems

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