Electrochemical immunosensors – A powerful tool for analytical applications

Felix, Fabiana S.; Angnes, Lúcio

doi:10.1016/j.bios.2017.11.029

Cited by 464 publications

(239 citation statements)

References 146 publications

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“…While various types of transducers have been investigated for pathogen biosensing (Lazcka et al 2007;Singh et al 2014;Yoo and Lee, 2016), including mechanical and optical transducers, such as cantilever biosensors or surface plasmon resonance (SPR)-based biosensors, electrochemical biosensors have been extensively applied to pathogen detection (Felix and Angnes, 2018;Pereira da Silva Neves et al 2018;Saucedo et al 2019). Electrochemical biosensors for pathogen detection utilize conducting and semiconducting materials as the transducer, which is commonly referred to as an electrode.…”

Section: Introductionmentioning

confidence: 99%

“…To date, electrochemical biosensors have enabled sample preparation-free detection of pathogens in various matrices, in situ detection of pathogens on surfaces, rapid pathogen detection using low-cost platforms, multiplexed detection of pathogens in practical matrices, and detection of pathogens via wireless actuation and data acquisition formats. As a result, electrochemical biosensors for pathogen detection have been widely examined for food and water safety, medical diagnostic, environmental monitoring, and bio-threat applications (Amiri et al 2018;Duffy and Moore, 2017;Felix and Angnes, 2018;Furst and Francis, 2019;Mishra et al 2018;Monz� o et al 2015;Rastogi and Singh, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical biosensors for pathogen detection

Cesewski

Johnson

2020

Biosensors and Bioelectronics

635

358

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A B S T R A C TRecent advances in electrochemical biosensors for pathogen detection are reviewed. Electrochemical biosensors for pathogen detection are broadly reviewed in terms of transduction elements, biorecognition elements, electrochemical techniques, and biosensor performance. Transduction elements are discussed in terms of electrode material and form factor. Biorecognition elements for pathogen detection, including antibodies, aptamers, and imprinted polymers, are discussed in terms of availability, production, and immobilization approach. Emerging areas of electrochemical biosensor design are reviewed, including electrode modification and transducer integration. Measurement formats for pathogen detection are classified in terms of sample preparation and secondary binding steps. Applications of electrochemical biosensors for the detection of pathogens in food and water safety, medical diagnostics, environmental monitoring, and bio-threat applications are highlighted. Future directions and challenges of electrochemical biosensors for pathogen detection are discussed, including wearable and conformal biosensors, detection of plant pathogens, multiplexed detection, reusable biosensors for process monitoring applications, and low-cost, disposable biosensors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical biosensors for pathogen detection

Cesewski

Johnson

2020

Biosensors and Bioelectronics

635

358

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“…Home glucose tests for monitoring diabetes are the most widely used, despite the existence of similar devices for diabetics based on the MediSense ® Optium TM platform . The vast majority of biosensors (devices designed to detect or quantify a biomolecule) described in the literature to date involve enzyme‐based biosensors (e. g., especially those based on glucose oxidase enzyme), whilst immunosensors (antibody‐based biosensors) are also fairly common . These devices belong to a family of affinity biosensors which are based on a strong interaction between antibodies and analyte molecules from a clinical sample (e. g., blood, serum, urine, saliva, etc .)…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point-of-care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.[a] Dr.

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“…These nanomaterials could be gold nanoparticles, carbon nanomaterials, magnetic nanoparticles or magnetic beads (MBs), silica nanoparticles, quantum dots (QDs) and hybrid nanostructures. 45 Khater et al developed a rapid, label-free impedimetric biosensor for citrus tristeza virus (CTV) detection using gold nanoparticles ( Figure 1C). 46 CTV (Family Closteroviridae) is a filamentous positive strand RNA virus that infects citrus trees (sour orange) and is transmitted through insect transmission by aphids.…”

Section: Nucleic Acid-based Sensorsmentioning

confidence: 99%

Review—Chemical and Biological Sensors for Viral Detection

Özer

Geiss

Henry

2019

J. Electrochem. Soc.

128

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Infectious diseases commonly occur in contaminated water, food, and bodily fluids and spread rapidly, resulting in death of humans and animals worldwide. Among infectious agents, viruses pose a serious threat to public health and global economy because they are often difficult to detect and their infections are hard to treat. Since it is crucial to develop rapid, accurate, cost-effective, and in-situ methods for early detection viruses, a variety of sensors have been reported so far. This review provides an overview of the recent developments in electrochemical sensors and biosensors for detecting viruses and use of these sensors on environmental, clinical and food monitoring. Electrochemical biosensors for determining viruses are divided into four main groups including nucleic acid-based, antibody-based, aptamer-based and antigen-based electrochemical biosensors. Finally, the drawbacks and advantages of each type of sensors are identified and discussed.

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Electrochemical immunosensors – A powerful tool for analytical applications

Cited by 464 publications

References 146 publications

Electrochemical biosensors for pathogen detection

Electrochemical biosensors for pathogen detection

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Review—Chemical and Biological Sensors for Viral Detection

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