Electrochemical impedance spectroscopy based microfluidic biosensor for the detection of circulating tumor cells

Burinaru, Tiberiu; Ţîncu, Bianca; Avram, Mărioara; Preda, Petruţa; Enciu, Ana‐Maria; Marculescu, Catalin; Constantin, Tiberiu; Militaru, M.

doi:10.1016/j.mtcomm.2022.104016

Cited by 20 publications

(25 citation statements)

References 31 publications

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“…69 IF within integrated platforms is performed by fixing cells within the channels, flowing staining reagents through, and conducting fluorescence imaging of the chip. For this reason, IF is ubiquitously used to validate CTC detection on platforms where the primary assay was completed by other means (e.g., electrochemical impedance spectroscopy (EIS) 112 or deformability cytometry 138 ).…”

Section: On-chip Integration Of Optical Ctc Detectionmentioning

confidence: 99%

“…162 As described earlier, the predominant means of CTC isolation prior to on-chip electrochemical assays are Abfunctionalised channels. 112,114 An exception to this, is the work of Safaei et al where CTCs were first enriched in whole blood by anti-EpCAM modified MNPs and subsequently assayed for on-chip using differential pulse voltammetry (DPV), this is an exemplar of an electrochemical ELISA arrangement. In DPV, the current response associated with the voltage pulse is recorded and analysed to examine the faradaic interactions at the electrode surface.…”

Section: Electrochemical Means Of Integrated On-chip Ctc Detectionmentioning

confidence: 99%

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The integrated on-chip isolation and detection of circulating tumour cells

Abusamra,

Barber,

Sharafeldin

et al. 2024

Sens. Diagn.

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Section: On-chip Integration Of Optical Ctc Detectionmentioning

confidence: 99%

Section: Electrochemical Means Of Integrated On-chip Ctc Detectionmentioning

confidence: 99%

The integrated on-chip isolation and detection of circulating tumour cells

Abusamra,

Barber,

Sharafeldin

et al. 2024

Sens. Diagn.

View full text Add to dashboard Cite

show abstract

“…Due to its benefits of being inexpensive, label-free [42], and simple to use, electro-chemical impedance spectroscopy (EIS) [43] has shown a high potential to be used in the cancer cell-detection. The charge transfer resistance increases when cells are interacted onto the sensor surface due to the inhibition of electron-transfer process between the solution and electrodes.…”

Section: Direct Detection Of Ctcsmentioning

confidence: 99%

Advanced electrocatalytic materials based biosensors for cancer cell detection – A review

et al. 2023

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Herein, we have highlighted the latest developments on biosensors for cancer cell detection. Electrochemical (EC) biosensors offer several advantages such as high sensitivity, selectivity, rapid analysis, portability, low‐cost, etc. Generally, biosensors could be classified into other basic categories such as immunosensors, aptasensors, cytosensors, electrochemiluminescence (ECL), and photo‐electrochemical (PEC) sensors. The significance of the EC biosensors is that they could detect several biomolecules in human body including cholesterol, glucose, lactate, uric acid, DNA, blood ketones, hemoglobin, and others. Recently, various EC biosensors have been developed by using electrocatalytic materials such as silver sulfide (Ag2S), black phosphene (BPene), hexagonal carbon nitrogen tube (HCNT), carbon dots (CDs)/cobalt oxy‐hydroxide (CoOOH), cuprous oxide (Cu2O), polymer dots (PDs), manganese oxide (MnO2), graphene derivatives, and gold nanoparticles (Au‐NPs). In some cases, these newly developed biosensors could be able to detect cancer cells with a limit of detection (LOD) of 1 cell/mL. In addition, many remaining challenges have to be addressed and validated by testing more real samples and confirm that these EC biosensors are more accurate and reliable to measure cancer cells in the blood and salivary samples.

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“…Notably, the integrated combination of microfluidic devices with other functional detection platforms, such as electrochemical sensors [ 141 ] and an electrophysiological detection platform [ 142 ], has been extensively designed and developed for multifunctional evaluation and complex signal detection of various types of biomolecules. Recently, commercial portable electrochemical sensors have rapidly emerged and the designed disposable electrochemical electrodes can be embedded in many compatible platforms.…”

Section: Future Prospectsmentioning

confidence: 99%

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

Chen

Tian

et al. 2022

Biosensors

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The biomimetic olfactory and gustatory biosensing devices have broad applications in many fields, such as industry, security, and biomedicine. The development of these biosensors was inspired by the organization of biological olfactory and gustatory systems. In this review, we summarized the most recent advances in the development of detection strategies for chemical sensing based on olfactory and gustatory biomimetic biosensors. First, sensing mechanisms and principles of olfaction and gustation are briefly introduced. Then, different biomimetic sensing detection strategies are outlined based on different sensing devices functionalized with various molecular and cellular components originating from natural olfactory and gustatory systems. Thereafter, various biomimetic olfactory and gustatory biosensors are introduced in detail by classifying and summarizing the detection strategies based on different sensing devices. Finally, the future directions and challenges of biomimetic biosensing development are proposed and discussed.

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Electrochemical impedance spectroscopy based microfluidic biosensor for the detection of circulating tumor cells

Cited by 20 publications

References 31 publications

The integrated on-chip isolation and detection of circulating tumour cells

The integrated on-chip isolation and detection of circulating tumour cells

Advanced electrocatalytic materials based biosensors for cancer cell detection – A review

Progress in the Development of Detection Strategies Based on Olfactory and Gustatory Biomimetic Biosensors

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