Electrochemical Investigation of Amoxicillin Interaction with Some Metal Ions Related to Complexation Process

Abstract

The reaction of amoxicillin (AMX) with transition metals such as Cu(II), Zn(II) and Fe(III) has been investigated electrochemically at graphite electrode (CPE) using square wave voltammetry (SWV). The oxidation peak of AMX often observed at 0.7 V was significantly affected by the presence of the studied transition metal ions. Indeed, after the addition of these metals, the oxidation potential and current variations were clearly observed in the voltammetric curves. The influence of metal ions concentration and reaction time on the electrochemical response of AMX was also studied. The electrochemical results proved that the oxidation processes of amoxicillin could be affected by transition metals complexation. The formation of Metal-AMX complexes was examined by SWV, UV-visible and infrared spectroscopy.