Electrochemical investigation of L-dopa and simultaneous resolution in the presence of uric acid and ascorbic acid at a poly (methyl orange) film coated electrode: A voltammetric study

Paracetamol (PA), being an analgesic and antipyretic medicine, can cause fatal hepatotoxicity and nephrotoxicity when overdosed. It is therefore important to develop electrochemical sensors that can monitor and quantify it in aquatic environments. In this study, rare‐earth sandwich‐type phthalocyaninato chelates based on neodymium (1 a) and samarium (1 b) were employed as electrocatalysts to modify glassy carbon electrodes (GCE) for the first time. It was found that 1 a‐modified GCE (herein referred to as 1 a‐GCE) is less conductive than 1 b‐modified counterpart (1 b‐GCE). A larger rate constant was also obtained for 1 b‐GCE. It was established that a faster oxidation rate efficiency was responsible for lower limit of detection value obtained for 1 b‐GCE as compared to 1 a‐GCE.

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“…: I pa = 0.0471 + 69.1 (R 2 = 0.9903) was determined according to Eqs. 5 and 6: [47][48][49][50] LOD ¼ 3…”

Section: Chronoamperometric Kinetics Of Pa and Analytical Performancementioning

confidence: 99%

Analytical Detection and Electrocatalysis of Paracetamol in Aqueous Media Using Rare‐Earth Double‐Decker Phthalocyaninato Chelates as Electrochemically Active Materials

2020

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“…The diluted methyldopa solutions were prepared by using diluting with Britton-Robinson (B-R) buffer solution from the stock solution (Reddaiah et al, 2012). A linear calibration curve was created in the B-R buffer solution (pH 7.40) with the DPV method in the concentration range of 0.020 µM and 70 µM methyldopa.…”

Section: Calibrationgraph For the Quantitative Determination Of Methymentioning

confidence: 99%

Development of Electrochemical Sensors for Quantitative Analysis of Methyldopa at Modified-Gce and Pge Electrodes by Voltammetry

et al. 2020

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CHIRP systems are widely used in seabed sediment classification, submarine faults, positioning of marine engineering structures, pipeline geotechnical studies, platform and well area assessments, archaeological and environmental impact assessments. The resolution of the system is in the order of decimeter. In this study, the characteristics of submarine active faults, buried faults, seabed and underlying layers in the region were analyzed and interpreted by CHIRP data collected off-shore Seferihisar, Teke Peninsula and Alaçatı.

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“…However, the major problem for voltammetric detection of L-dopa in real samples is the interference of the concomitant compounds, such as ascorbic acid (AA) and uric acid (UA), which generally results in overlapped voltammetric response due to their very similar oxidation peak potentials on unmodified carbon electrodes [26,27]. Nowadays, chemically-modified electrode surface has been proved to be a successful strategy to circumvent this problem, and various materials and techniques have been used [28][29][30]. During the polymerization, an anodic peak corresponding to the oxidation of sulfacetamide descended gradually with cycles and tended to be stable after 20 cycles.…”

Section: Reagents and Solutionsmentioning

confidence: 99%

Stripping Voltammetric Determination of L-dopa using Poly Sulfacetamide Modified Glassy Carbon Electrode

2016

Assiut University Journal of Multidisciplinary Scientific Resea

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The voltammetric behavior of L-dopa was studied at poly sulfacetamide modified glassy carbon electrode (SFA-modified GCE), based on electrochemical oxidation of sulfacetamide. The modified electrode exhibited good selectivity and strong electrocatalytic activity for electrochemical oxidation of L-dopa in Britton -Robinson buffer solution (pH 2). Under the chosen conditions, the oxidation peak currents showed a linear dependence on the L-dopa concentration in the range of 1×10 -7 to 1.1×10 -6 M with limit of detection of 0.3×10 -9 M. This method was applied to the determination of L-dopa in human serum and urine with satisfactory results. In addition, L-dopa was determined in presence of ascorbic acid (AA), uric acid (UA) and glucose.

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Electrochemical investigation of L-dopa and simultaneous resolution in the presence of uric acid and ascorbic acid at a poly (methyl orange) film coated electrode: A voltammetric study

Cited by 56 publications

References 44 publications

Analytical Detection and Electrocatalysis of Paracetamol in Aqueous Media Using Rare‐Earth Double‐Decker Phthalocyaninato Chelates as Electrochemically Active Materials

Analytical Detection and Electrocatalysis of Paracetamol in Aqueous Media Using Rare‐Earth Double‐Decker Phthalocyaninato Chelates as Electrochemically Active Materials

Development of Electrochemical Sensors for Quantitative Analysis of Methyldopa at Modified-Gce and Pge Electrodes by Voltammetry

Stripping Voltammetric Determination of L-dopa using Poly Sulfacetamide Modified Glassy Carbon Electrode

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