Electrochemical Investigations of the Anticancer Drug Idarubicin Using Multiwalled Carbon Nanotubes Modified Glassy Carbon and Pyrolytic Graphite Electrodes

Abstract

The effect of surface modifications on the electrochemical behavior of the anticancer drug idarubicin was studied at multiwalled carbon nanotubes modified glassy carbon and edge plane pyrolytic graphite electrodes. The surface morphology of the modified electrodes was characterized by scanning electron microscopy. The modified electrodes were constructed for the determination of idarubicin using adsorptive stripping differential pulse voltammetry. The experimental parameters such as supporting electrolyte, pH, accumulation time and potential, amount of carbon nanotubes for the sensitive assay of idarubicin were studied as details. Under the optimized conditions, idarubicin gave a linear response in the range 9.36 10 À8 -1.87 10 À6 M for modified glassy carbon and 9.36 10 À8 -9.36 10 À7 M for modified edge plane pyrolytic graphite electrodes. The detection limits were found as 1.87 10 À8 M and 3.75 10 À8 M based on modified glassy carbon and edge plane pyrolytic graphite electrodes, respectively. Interfering species such as ascorbic acid, dopamine, and aspirin showed no interference with the selective determination of idarubicin. The analyzing method was fully validated and successfully applied for the determination of idarubicin in its pharmaceutical dosage form. The possible oxidation mechanism of idarubicin was also discussed. The results revealed that the modified electrodes showed an obvious electrocatalytic activity toward the oxidation of idarubicin by a remarkable enhancement in the current response compared with bare electrodes.

Polyaniline–DNA based sensor for the detection of anthracycline drugs

“…Various carbon materials were implemented in aminated dendrimer coating with determination down to 0.13 µM of doxorubicin [48]. Modification of GCE with carbon nanotubes resulted in detection of 20-500 nM of daunorubicin [49] and 18.7 nM idarubicin [50]. In most cases described, the stage of preaccumulation is required and no specific interactions with DNA are used.…”

A Novel Strategy for Simultaneous Determination of Dopamine and Uric Acid Using a Carbon Paste Electrode Modified with CdTe Quantum Dots

“…There is no need for derivatization or time-consuming extraction steps in comparison with other techniques because electroanalytical methods are less sensitive to the matrix effects [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. There is no need for derivatization or time-consuming extraction steps in comparison with other techniques because electroanalytical methods are less sensitive to the matrix effects [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

“…Although, there are many reports about the simultaneous determination of dopamine and uric acid using electron transfer mediators [29][30][31][32][33][34], but in this study, we report the preparation and application of a CdTe quantum dots-modified carbon paste electrodes for the simultaneous determination of dopamine and uric acid without any additional modification such as addition of electron transfer mediator or specific reagents for the first time. Although, there are many reports about the simultaneous determination of dopamine and uric acid using electron transfer mediators [29][30][31][32][33][34], but in this study, we report the preparation and application of a CdTe quantum dots-modified carbon paste electrodes for the simultaneous determination of dopamine and uric acid without any additional modification such as addition of electron transfer mediator or specific reagents for the first time.…”

Electrochemical Biosensors Based on Native DNA and Nanosized Mediator for the Detection of Anthracycline Preparations

“…The analyte was first accumulated from acetate buffer solution, pH 4.5, and then the electrode is transferred in another buffer solution and differential pulse voltammogram is recorded. In similar conditions, the LOD of idarubicin was found to be 18.7 nM [47]. The use of GCE modified with carbon nanotubes and silver nanoparticles made it possible to detect 1.7 nM of doxorubicin [44].…”