2023
DOI: 10.3390/mi14010138
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Electrochemical Micro-Immunosensor of Cubic AuPt Dendritic Nanocrystals/Ti3C2-MXenes for Exosomes Detection

Abstract: Exosomes are extracellular vesicles that exist in body circulation as intercellular message transmitters. Although the potential of tumor-derived exosomes for non-invasive cancer diagnosis is promising, the rapid detection and effective capture of exosomes remains challenging. Herein, a portable electrochemical aptasensor of cubic AuPt dendritic nanocrystals (AuPt DNs)/Ti3C2 assisted in signal amplification, and aptamer CD63 modified graphene oxide (GO) was immobilized on a screen-printed carbon electrode (SPC… Show more

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Cited by 5 publications
(3 citation statements)
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“…195 Electrochemical sensors for microorganisms using MXene-based nanomaterials are summarized in Table 4. Exosomes, [196][197][198][199] bacteria, [200][201][202][203][204][205] viruses, 149,[206][207][208][209] and even cancer cells 114,171 can be measured through appropriate surface modification of electrodes. The lowest sensing range is about 10 particles per mL.…”
Section: The Applications Of Mxenes In Microorganism Sensorsmentioning
confidence: 99%
“…195 Electrochemical sensors for microorganisms using MXene-based nanomaterials are summarized in Table 4. Exosomes, [196][197][198][199] bacteria, [200][201][202][203][204][205] viruses, 149,[206][207][208][209] and even cancer cells 114,171 can be measured through appropriate surface modification of electrodes. The lowest sensing range is about 10 particles per mL.…”
Section: The Applications Of Mxenes In Microorganism Sensorsmentioning
confidence: 99%
“…(b) An electrochemical immunosensor for the efficient detection of colorectal cancer-derived exosomes. Reproduced by permission from [ 182 ], copyright [2023, Micromachines]. (c) Sandwich electrochemical aptasensor for PD-L1+ exosome analysis.…”
Section: Nanoarchitectonics Based Electrochemical Biosensing For Impr...mentioning
confidence: 99%
“…The cubic structured AuPt DNs/Ti 3 C 2 -aptamer hybridized nanostructure exhibited efficient recognition of exosomes with a detection limit down to 20 particles/µL. This proposed electrochemical biosensor holds clinical value for early cancer detection [ 182 ]. Detection of PD-L1+ exosomes necessitates an extremely sensitive detection technique.…”
Section: Nanoarchitectonics Based Electrochemical Biosensing For Impr...mentioning
confidence: 99%