Electrochemical modulation of sickle cell haemoglobin polymerisation

Iqbal, Zeshan; McKendry, Rachel A.; Horton, Michael A.; Caruana, Daren J.

doi:10.1039/b613381a

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2007

DOI: 10.1039/b613381a

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Electrochemical modulation of sickle cell haemoglobin polymerisation

Zeshan Iqbal

Rachel A. McKendry

Michael A. Horton

et al.

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2013

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Investigation of Sickle‐Cell Haemoglobin Polymerisation under Electrochemical Control

Iqbal

McKendry

et al. 2013

ChemPhysChem

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We describe an electrochemistry-based technique to control and monitor the polymerisation of sickle-cell haemoglobin (HbS). The polymerisation was monitored as a change in turbidity during the depletion of oxygen in a small volume custom-built thin-layer electrochemical cell. The cell allowed the investigation of HbS polymerisation as a function of HbS concentration, temperature and solution pH. We confirm that the oxygen was efficiently depleted using finite-element modelling to accurately recreate the electrochemical thin-layer cell. Understanding the nucleation and growth of HbS polymerisation will provide a better understanding of the pathophysiology of sickle-cell disease in vivo, and thus help improve therapeutic strategies for this common and frequently disabling disorder.

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Investigation of Sickle‐Cell Haemoglobin Polymerisation under Electrochemical Control

Iqbal

McKendry

et al. 2013

ChemPhysChem

Self Cite

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Electrochemical modulation of sickle cell haemoglobin polymerisation

Cited by 1 publication

References 53 publications

Investigation of Sickle‐Cell Haemoglobin Polymerisation under Electrochemical Control

Investigation of Sickle‐Cell Haemoglobin Polymerisation under Electrochemical Control

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