Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

Abstract

Objective: This study was undertaken to propose electro-oxidation mechanism and to develop a selective and sensitive method for the determination of an anti-cancer drug, pemetrexed disodium (PTD). Methods:The electrochemical oxidation of anti-cancer drug PTD has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentration, scan rate, and excipients were investigated to optimize the experimental conditions.Results: According to the liner relation between peak potential, peak current, scan rate and PTD concentration, differential pulse voltammetric method for the quantitative determination in phosphate buffer solution was developed. The linear response was obtained in the range of 10 μM to 0.75 μM with a detection limit of 0.19 μM. The electrochemical oxidation of mechanism of anti-cancer drug PTD was proposed. Conclusion:The proposed method is rapid and does not include any time-consuming steps. The simplicity, sensitivity, and low cost of analysis are the main features of the proposed method for the determination of PTD.