Electrochemical oxidation of Atorvastatin using graphene oxide and surfactant-based sensor

Sawkar, Rakesh R.; Patil, Vinoda B.; Tuwar, Suresh M.

doi:10.1016/j.matpr.2022.08.192

Cited by 10 publications

(3 citation statements)

References 27 publications

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“…These drawbacks can be resolved using sensitive and selective electrode materials with various modifications [16]. In recent years, chemical and biological sensors have significantly impacted medical examination, personal safety, and the environmental and agricultural fields [17][18][19]. However, the efficient operation of an electrochemical sensor mainly depends on the appropriate sensing material.…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

et al. 2022

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A nanocomposite electrode of graphene (Gr) and zinc oxide (ZnO) nanoparticles was fabricated to study the electrochemical oxidation behavior of an anti-inflammatory drug, i.e., cetirizine (CET). The voltametric response of CET for bare CPE, Gr/CPE, ZnO/CPE, and the ZnO-Gr nanocomposite electrode was studied. The modifier materials were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray powder diffraction (XRD) to comprehend the surface morphology of the utilized modifiers. The influence of pH, scan rate, and accumulation time on the electrooxidation of CET was examined. It was found that the electrochemical oxidation of CET was diffusion-controlled, in which two protons and two electrons participated. The detection limit was found to be 2.8 × 10−8 M in a linearity range of 0.05–4.0 µM. Study of excipients was also performed, and it was found that they had negligible interference with the peak potential of CET. The validation and utility of the fabricated nanocomposite sensor material were examined by analyzing clinical and biological samples. Stability testing of the nanocomposite electrode was conducted to assess the reproducibility, determining that the developed biosensor has good stability and high efficiency in producing reproducible results.

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Section: Introductionmentioning

confidence: 99%

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

et al. 2022

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“…Electrochemical sensors have recently aroused the scientific community’s interest and have been frequently employed as sensitive detection techniques [ 19 , 20 ]. Rapid reaction, high sensitivity and selectivity, beneficial portability, simple sample preparation process, and cost-effective and simple design are the advantages of these approaches [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Glucose Incorporated Graphite Matrix for Electroanalysis of Trimethoprim

et al. 2022

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The antibiotic drug trimethoprim (TMP) is used to treat bacterial infections in humans and animals, and frequently TMP is used along with sulfonamides. However, a large portion of TMP is excreted in its active state, which poses a severe problem to humans and the environment. A sensitive, rapid, cost-effective analytical tool is required to monitor the TMP concentration in biological and environmental samples. Hence, this study proposed an analytical methodology to analyze TMP in clinical, biological and environmental samples. The investigations were carried out using a glucose-modified carbon paste electrode (G-CPE) employing voltammetric techniques. Electrochemical behavior was examined with 0.5 mM TMP solution at optimum pH 3.4 (Phosphate Buffer Solution, I = 0.2 M). The influence of scan rate on the electro-oxidation of TMP was studied within the range of 0.05 to 0.55 V/s. The effect of pH and scan rate variations revealed proton transfer during oxidation. Moreover, diffusion phenomena governed the irreversibility of the electrode reaction. A probable and suitable electrode interaction and reaction mechanism was proposed for the electrochemical oxidation of TMP. Further, the TMP was quantitatively estimated with the differential pulse voltammetry (DPV) technique in the concentration range from 9.0 × 10−7 to 1.0 × 10−4 M. The tablet, spiked water and urine analysis demonstrated that the selected method and developed electrode were rapid, simple, sensitive, and cost-effective.

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“…Electrochemical techniques have been widely used to determine various chemicals and biological components in multiple samples [14][15][16]. Electrochemical procedures are rapid, sensitive, and cost-efficient and can be miniaturized for portability [17,18]. Recently, nanomaterials-based electrochemical sensors have been advanced to investigate a variety of analyte molecules [19,20].…”

Section: Introductionmentioning

confidence: 99%

Sodium Dodecyl Sulfate–Mediated Graphene Sensor for Electrochemical Detection of the Antibiotic Drug: Ciprofloxacin

et al. 2022

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The present study involves detecting and determining CIP by a new electrochemical sensor based on graphene (Gr) in the presence of sodium dodecyl sulfate (SDS) employing voltammetric techniques. Surface morphology studies of the sensing material were analyzed using a scanning electron microscope (SEM) and atomic force microscope (AFM). In the electroanalysis of CIP at the developed electrode, an enhanced anodic peak response was recorded, suggesting the electro-oxidation of CIP at the electrode surface. Furthermore, we evaluated the impact of the electrolytic solution, scan rate, accumulation time, and concentration variation on the electrochemical behavior of CIP. The possible electrode mechanism was proposed based on the acquired experimental information. A concentration variation study was performed using differential pulse voltammetry (DPV) in the lower concentration range, and the fabricated electrode achieved a detection limit of 2.9 × 10−8 M. The proposed sensor detected CIP in pharmaceutical and biological samples. The findings displayed good recovery, with 93.8% for tablet analysis and 93.3% to 98.7% for urine analysis. The stability of a developed electrode was tested by inter- and intraday analysis.

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Electrochemical oxidation of Atorvastatin using graphene oxide and surfactant-based sensor

Cited by 10 publications

References 27 publications

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

Glucose Incorporated Graphite Matrix for Electroanalysis of Trimethoprim

Sodium Dodecyl Sulfate–Mediated Graphene Sensor for Electrochemical Detection of the Antibiotic Drug: Ciprofloxacin

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