Electrochemical oxidative selective halogenation of pyrazolones for the synthesis of 4-halopyrazolones

Li, Minghan; Yang, Shilin; Zhang, Jingyi; Gao, Zixun; Zheng, Linyu; Lu, Fangling; Feng, Yulin

doi:10.1039/d4ob00982g

Org. Biomol. Chem.

2024

DOI: 10.1039/d4ob00982g

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Electrochemical oxidative selective halogenation of pyrazolones for the synthesis of 4-halopyrazolones

Minghan Li,

Shilin Yang,

Jingyi Zhang

et al.

Abstract: An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been developed under conditions free of metals, external oxidants, and external supporting electrolytes. The reaction demonstrates good functional...

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Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds

Guimarães,

Graça,

Diogo

et al. 2024

Chemistry An Asian Journal

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An eco‐friendly electrochemical halogenation of 2‐amino‐1,4‐naphthoquinones has been developed. The new mild and energy efficient methodology comprises sustainable features like oxidant free and double role of the halogen source as electrolyte, originating twenty‐six amino‐halogenated naphthoquinoidal derivatives in good yields under mild conditions. This novel methodology permitted access to new potent trypanocidal prototypes, where six compounds were more active than benznidazole, the current market drug used in the treatment of Chagas Disease.

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Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds

Guimarães,

Graça,

Diogo

et al. 2024

Chemistry An Asian Journal

View full text Add to dashboard Cite

show abstract

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Electrochemical oxidative selective halogenation of pyrazolones for the synthesis of 4-halopyrazolones

Abstract: An efficient and environmentally friendly electrochemical oxidative selective halogenation of pyrazolones has been developed under conditions free of metals, external oxidants, and external supporting electrolytes. The reaction demonstrates good functional...

Cited by 1 publication

References 37 publications

Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds

Electrochemical Halogenation of Naphthoquinones: A Modular and Sustainable Strategy Towards Trypanocidal Compounds

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