Electrochemical Preparation of Synergistic Nanoantimicrobials

Sportelli, Maria Chiara; Longano, Daniela; Bonerba, Elisabetta; Tantillo, Giuseppina; Torsi, Luisa; Sabbatini, Luigia; Cioffi, Nicola

doi:10.3390/molecules25010049

Cited by 18 publications

(18 citation statements)

References 34 publications

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“…The embedding of metal nanoparticles (copper ones, in principle) in polymer matrices could help in the tuning of metal release properties, and at the same time in minimizing the risk of nanoparticle release into the environment [53]. Moreover, very simple and reliable routes to synergistic nanoparticles combining a copper core and a quaternary ammonium shell (both of which are capable, in principle, of expressing a strong antiviral action) are available in recent literature [63].…”

Section: Antiviral Drug Virus Infection Action Mechanism Referencesmentioning

confidence: 99%

Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?

et al. 2020

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Since 2004, we have been developing nanomaterials with antimicrobial properties, the so-called nanoantimicrobials. When the coronavirus disease 2019 (COVID-19) emerged, we started investigating new and challenging routes to nanoantivirals. The two fields have some important points of contact. We would like to share with the readership our vision of the role a (nano)materials scientist can play in the fight against the COVID-19 pandemic. As researchers specifically working on surfaces and nanomaterials, in this letter we underline the importance of nanomaterial-based technological solutions in several aspects of the fight against the virus. While great resources are understandably being dedicated to treatment and diagnosis, more efforts could be dedicated to limit the virus spread. Increasing the efficacy of personal protection equipment, developing synergistic antiviral coatings, are only two of the cases discussed. This is not the first nor the last pandemic: our nanomaterials community may offer several technological solutions to challenge the ongoing and future global health emergencies. Readers' feedback and suggestions are warmly encouraged.

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Section: Antiviral Drug Virus Infection Action Mechanism Referencesmentioning

confidence: 99%

Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?

et al. 2020

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“…The study revealed that metal-loaded nanocomposites or metal embedded copper nanoparticles in polymer matrices are very effective against viral pathogens. Moreover, the combination of copper nanoparticles with quaternary ammonium shell exhibits potential antiviral activity [57].…”

Section: Nanoparticles-based Antiviral Coatingsmentioning

confidence: 99%

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

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Yadav

et al. 2020

Expert Review of Anti-infective Therapy

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Introduction: COVID-19 pandemic has been declared as a global emergency by the World Health Organization which has mounted global pressure on the healthcare system. The design and development of rapid tests for the precise and early detection of infection are urgently needed to detect the disease and also for bulk screening of infected persons. The traditional drugs moderately control the symptoms, but so far, no specific drug has been discovered. The prime concern is to device novel tools for rapid and precise diagnosis, drug delivery, and effective therapies for coronavirus. In this context, nanotechnology offers novel ways to fight against COVID-19. Area covered: This review includes the use of nanomaterials for the control of COVID-19. The tools for diagnosis of coronavirus, nano-based vaccines, and nanoparticles as a drug delivery system for the treatment of virus infection have been discussed. The toxicity issues related to nanoparticles have also been addressed. Expert opinion: The research on nanotechnology-based diagnosis, drug delivery, and antiviral therapies is at a preliminary stage. The antiviral nanomedicine therapies are cost-effective and with high quality. Nanoparticles are a promising tool for prevention, diagnosis, antiviral drug delivery, and therapeutics, which may open up new avenues in the treatment of COVID-19.

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“…When the asymmetric salt BDHAC was used as a stabilizer, the electrochemical parameters did not lead to the same optimal results, and fast precipitation and NP aggregation were observed. Therefore, an increased surfactant concentration was used with the aim of inducing a greater stabilizing effect and balancing the smaller steric hindrance of BDHAC as a shell-forming component [44]. Moreover, THF was tested as a single solvent to prevent phase separation during CuNP inclusion in the NVs.…”

Section: Synthesis and Morphological Characterization Of Cunpsmentioning

confidence: 99%

“…Therefore, an increased surfactant concentration was used with the aim of inducing a greater stabilizing effect and balancing the smaller steric hindrance of BDHAC as a shell-forming component [44]. Moreover, THF was tested as a single solvent to prevent phase separation during CuNP inclusion in the NVs.…”

Section: Synthesis and Morphological Characterization Of Cunpsmentioning

confidence: 99%

“…Cu@TDoAC showed the best colloidal stability and narrower size distribution, hence, it was chosen for the first NP inclusion test. On the other hand, Cu@BDHAC was selected-despite some partial aggregation occurring after a few days-because of its widely proven biocompatibility and antimicrobial properties [21], to exploit the synergistic effect with copper [44] when inserted in the NVs. The Cu@TDoAC-and Cu@BDHAC-loaded NVs were characterized and compared in order to further investigate a possible antibiofilm action exerted by the CuNPs combined with the disinfection properties of the quaternary ammonium compounds (part II).…”

Section: Preparation and Characterization Of Np-loaded Nvsmentioning

confidence: 99%

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Cu Nanoparticle-Loaded Nanovesicles with Antibiofilm Properties. Part I: Synthesis of New Hybrid Nanostructures

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Copper nanoparticles (CuNPs) stabilized by quaternary ammonium salts are well known as antimicrobial agents. The aim of this work was to study the feasibility of the inclusion of CuNPs in nanovesicular systems. Liposomes are nanovesicles (NVs) made with phospholipids and are traditionally used as delivery vehicles because phospholipids favor cellular uptake. Their capacity for hydrophilic/hydrophobic balance and carrier capacity could be advantageous to prepare novel hybrid nanostructures based on metal NPs (Me-NPs). In this work, NVs were loaded with CuNPs, which have been reported to have a biofilm inhibition effect. These hybrid materials could improve the effect of conventional antibacterial agents. CuNPs were electro-synthesized by the sacrificial anode electrolysis technique in organic media and characterized in terms of morphology through transmission electron microscopy (TEM). The NVs were prepared by the thin film hydration method in aqueous media, using phosphatidylcholine (PC) and cholesterol as a membrane stabilizer. The nanohybrid systems were purified to remove non-encapsulated NPs. The size distribution, morphology and stability of the NV systems were studied. Different quaternary ammonium salts in vesicular systems made of PC were tested as stabilizing surfactants for the synthesis and inclusion of CuNPs. The entrapment of charged metal NPs was demonstrated. NPs attached preferably to the membrane, probably due to the attraction of their hydrophobic shell to the phospholipid bilayers. The high affinity between benzyl-dimethyl-hexadecyl-ammonium chloride (BDHAC) and PC allowed us to obtain stable hybrid NVs c.a. 700 nm in diameter. The stability of liposomes increased with NP loading, suggesting a charge-stabilization effect in a novel antibiofilm nanohybrid material.

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Electrochemical Preparation of Synergistic Nanoantimicrobials

Cited by 18 publications

References 34 publications

Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?

Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

Cu Nanoparticle-Loaded Nanovesicles with Antibiofilm Properties. Part I: Synthesis of New Hybrid Nanostructures

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