Electrochemical reactions of carboxylic acids and related processes

Eberson, Lennart

doi:10.1002/9780470771099.ch2

Cited by 12 publications

(8 citation statements)

References 101 publications

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“…The gas transfer does not depend on bubble formation at the membrane, but on a continuous source of dissolved gas at the membrane surface. The electrolyte is chosen to generate the desired gas (Eberson, 1969;Gileadi and Piersma, 1966;Petrucci, 1982). The only gas sources for the microreactor cultures are the electrolysis chambers; the microreactor housing is continuously sparged with sterile nitrogen and contains an oxygen scavenger pack.…”

Section: Resultsmentioning

confidence: 99%

“…As examples, 0.5M phosphate buffer (NaH 2 PO 4 Á2H 2 O, Na 2 HPO 4 , pH 7.2) is used to generate oxygen and hydrogen via water electrolysis, while the oxidation of formic acid is used to generate carbon dioxide and hydrogen (Fig. 1c,d) (Eberson, 1969;Gileadi and Piersma, 1966;Petrucci, 1982). An electrolyte solution of 1M HCOOK (potassium formate) in methanol was also considered but the permeation of evaporated methanol into the culture via the silicone membrane was a concern.…”

Section: Resultsmentioning

confidence: 99%

“…In the case of difficult-to-cultivate microorganisms, hydrogen, methane, ethane, carbon dioxide, and other gases could be generated by electrolysis, allowing growth of methanogens, methanotrophs, and many diverse microorganisms (Eberson, 1969;Gileadi and Piersma, 1966;Hori et al, 2002;Petrucci, 1982). Electrolysis is particularly useful for establishing repeatable microaerobic or microgas conditions.…”

Section: Discussionmentioning

confidence: 99%

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Microbioreactor arrays with parametric control for high‐throughput experimentation

Maharbiz

Holtz

Howe

et al. 2003

Biotech & Bioengineering

111

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A scalable array technology for parametric control of high-throughput cell cultivations is demonstrated. The technology makes use of commercial printed circuit board (PCB) technology, integrated circuit sensors, and an electrochemical gas generation system. We present results for an array of eight 250 microl microbioreactors. Each bioreactor contains an independently addressable suite that provides closed-loop temperature control, generates feed gas electrochemically, and continuously monitors optical density. The PCB technology allows for the assembly of additional off-the-shelf components into the microbioreactor array; we demonstrate the use of a commercial ISFET chip to continuously monitor culture pH. The electrochemical dosing system provides a powerful paradigm for reproducible gas delivery to high-density arrays of microreactors. Growth data are presented for Escherichia coli cultured in the array with varying microaerobic conditions using electrochemically generated oxygen. Additionally, we present data on carbon dioxide generation for pH dosing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Microbioreactor arrays with parametric control for high‐throughput experimentation

Maharbiz

Holtz

Howe

et al. 2003

Biotech & Bioengineering

111

View full text Add to dashboard Cite

show abstract

“…1c, d) (Eberson 1969;Gileadi and Piersma 1966;Petrucci 1982). An electrolyte solution of 1M HCOOK (potassium formate) in methanol was also considered but the permeation of evaporated methanol into the culture via the silicone membrane was a concern.…”

Section: Results With the First Generation Arraysmentioning

confidence: 99%

“…As the parameters of the membrane are constant and repeatable, the gas transfer rate into the culture is very well defined. The electrolyte is chosen to generate the desired gas (Eberson 1969;Gileadi and Piersma 1966;Petrucci 1982). The only gas sources for the microreactor cultures are the electrolysis chambers.…”

Section: Results With the First Generation Arraysmentioning

confidence: 99%

Physiomics Array: A Platform for Genome Research and Cultivation of Difficult-to-Cultivate Microorganisms Final Technical Report

Keasling¹

2006

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A scalable array technology for parametric control of high-throughput cell cultivations is demonstrated. The technology makes use of commercial printed circuit board (PCB) technology, integrated circuit sensors, and an electrochemical gas generation system. We present results for an array of eight 250 μl microbioreactors. Each bioreactor contains an independently addressable suite that provides closed-loop temperature control, generates feed gas electrochemically, and continuously monitors optical density. The PCB technology allows for the assembly of additional off-the-shelf components into the microbioreactor array; we demonstrate the use of a commercial ISFET chip to continuously monitor culture pH. The electrochemical dosing system provides a powerful paradigm for reproducible gas delivery to high-density arrays of microreactors. We have scaled the technology to a standard 96-well format and have constructed a system that could be easily assembled.

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The Organic Photochemistry of Silver and Gold

Horspool

2009

Patai's Chemistry of Functional Groups

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Introduction Reactions Involving Silver as Films or in Solution Photochemistry of Silver Complexes of Alkenes Silver–Carbon Bond Fission on Photolysis Silver Salts of Carboxylic Acids Reactions with Silver Triflate Amine Complexes of Silver Miscellaneous Reactions Involving Silver Monolayers on Gold Gold Complexes Gold as a Catalyst Carbon–Gold Bond Fission Miscellaneous Reactions Involving Gold

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Electrochemical reactions of carboxylic acids and related processes

Cited by 12 publications

References 101 publications

Microbioreactor arrays with parametric control for high‐throughput experimentation

Microbioreactor arrays with parametric control for high‐throughput experimentation

Physiomics Array: A Platform for Genome Research and Cultivation of Difficult-to-Cultivate Microorganisms Final Technical Report

The Organic Photochemistry of Silver and Gold

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