Electrochemical recognition of tryptophan enantiomers using a multi-walled carbon nanotube@polydopamine composite loaded with copper(II)

Qian, Junjuan; Yi, Yinhui; Zhang, Depeng; Zhu, Gangbing

doi:10.1007/s00604-019-3469-7

Cited by 32 publications

(16 citation statements)

References 35 publications

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“…The DPV peaks of l -Trp and d -Trp, respectively, deviated 92 and 137 mV toward positive potential away from 0.648 V on bare GCE. The result indicated that the asymmetric urchin structure of CMOF , is really effective in discriminating l / d -Trp via potential shifting difference, which corresponds to the strong interaction between the cupric ion and Trp . However, the ambiguous DPV curve with a low peak current still restricted the sensitivity of the urchin-CMOF interface, especially at a low concentration of Trp.…”

Section: Resultsmentioning

confidence: 96%

Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan

Guo

Wei

Lian

et al. 2020

ACS Appl. Nano Mater.

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An urchin-like chiral metal–organic framework/reduced graphene oxide (urchin-CMOF/rGO) nanocomposite was developed as the electrochemical sensing interface for robust, efficient, and high-selective discrimination of tryptophan (Trp) enantiomers. An urchin-CMOF/rGO nanocomposite was elaborately integrated to combine the amplification of electrical conduction by rGO and the enantioselectivity by asymmetric CMOF. On the basis of this novel nanocomposite-mediated sensor, chiral recognition of d/l-Trp was successfully achieved by the differential potential ratiometric method. Different percentages of Trp racemic mixtures were determined in a good linear relationship with specific peak potentials, which effectively detours the nonspecific signal of concomitant interference from most current-based voltammetries. Even in the complex human cerebrospinal fluid, the simulative ratiometric results of Trp-spiked samples were accurately detected with low false negatives. Additionally, diverse CMOF-regulated hybrid materials have great potential for chiral recognition in pharmaceutical monitoring and biochemical analysis.

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Section: Resultsmentioning

confidence: 96%

Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan

Guo

Wei

Lian

et al. 2020

ACS Appl. Nano Mater.

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“…To further improve the sensitivity and detection level of modified electrochemical sensors with CNTs and PDA, the incorporation of nanoparticles and ions has been used as a strategy for signal amplification of the modified sensors. For example, nanocomposites containing nanoparticles can improve electron transfer and increase the number of active sites [ 67 , 68 ]. Gold nanoparticles (AuNPs) are the most used due to their advantages, such as simple surface modification, electrocatalytic properties, and biocompatibility [ 69 ].…”

Section: Nanotubesmentioning

confidence: 99%

Recent progress and future perspectives of polydopamine nanofilms toward functional electrochemical sensors

2023

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Since its discovery in 2007, polydopamine nanofilms have been widely used in many areas for surface functionalization. The simple and low-cost preparation method of the nanofilms with tunable thickness can incorporate amine and oxygen-rich chemical groups in virtually any interface. The remarkable advantages of this route have been successfully used in the field of electrochemical sensors. The self-adhesive properties of polydopamine are used to attach nanomaterials onto the electrode’s surface and add chemical groups that can be explored to immobilize recognizing species for the development of biosensors. Thus, the combination of 2D materials, nanoparticles, and other materials with polydopamine has been successfully demonstrated to improve the selectivity and sensitivity of electrochemical sensors. In this review, we highlight some interesting properties of polydopamine and some applications where polydopamine plays an important role in the field of electrochemical sensors. Graphical Abstract

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“…42 Chitosan, excellent optical activity and large amounts of chiral sites, is widely used for the construction of electrochemical chiral nanoarchitectonics benefiting from excellent hydrophilicity, good adhesion,and easy film formation. 43,44 β-Cyclodextrin has 35 chiral centers, which is suitable for host−guest interactions for chiral recognition, such as moxifloxacin hydrochloride, DOPA, or tryptophan enantiomers, through SAMs on various solid substrates. 45 Perhaps the most interesting examples of chirality among biomolecules are the enzymes.…”

Section: Soft Nanoarchitectonics Based Chiral Recognitionmentioning

confidence: 99%

“…Furthermore, based on this amino acid–metal complex and DNAzyme, we extended this work to develop a DNA hybridization chain reaction strategy for electrochemical selective detection of carnitine enantiomers . Chitosan, having excellent optical activity and large amounts of chiral sites, is widely used for the construction of electrochemical chiral nanoarchitectonics benefiting from excellent hydrophilicity, good adhesion,and easy film formation. , β-Cyclodextrin has 35 chiral centers, which is suitable for host–guest interactions for chiral recognition, such as moxifloxacin hydrochloride, DOPA, or tryptophan enantiomers, through SAMs on various solid substrates …”

Section: Soft Nanoarchitectonics Based Chiral Recognitionmentioning

confidence: 99%

Soft Nanoarchitectonics for Enantioselective Biosensing

et al. 2020

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Conspectus Chirality is a fundamental property of a molecule, and the significant progress in chirality detection and quantification of a molecule has inspired major advances in various fields ranging from chemistry, biology, to biotechnology and pharmacology. Chiral molecules have identical molecular formulas, atom-to-atom linkages, and bonding distances, and as such they are difficult to distinguish both sensitively and selectively. Today, most new drugs and those under development are chiral, which requires technological developments in the separation and detection of chiral molecules. Therefore, rapid and facile methods to detect and discriminate chiral compounds are necessary to accelerate advances in many research fields. The challenges in analysis stem from the obvious fact that chiral molecules have the same physical properties. Although significant progress on the detection of enantiomeric composition has been achieved in the past decade, in order to fully realize the capacity of chiral molecular interrogation, highly sensitive and selective, portable, and easy-to-use detection remains challenging because of the limitation of conventional techniques. Soft nanoarchitectonics is a new concept for the fabrication of functional soft material systems through harmonization of various actions including atomic/molecular-level manipulation, chemical reactions, self-assembly and self-organization, and their modulation by external fields/stimuli. Soft nanoarchitectonics has been widely used as a key enabling technology for integrating predefined molecular functionalities including electrochemical, optical, catalytic, or biological properties into biosensing devices, which provides exciting opportunities to design, assemble, and fabricate tailored nanosystems to enable new sensing strategies for chiral molecules. In this Account, we aim to concisely discuss how these molecule-inspired soft nanoarchitectonics work for enantioselective sensing. We will first outline the basic principle and mechanistic insights of the soft nanoarchitectonics approach for enantioselective sensing, and then we will describe the new breakthroughs and trends in the area that have been most recently reported by our groups and others. There will also be a discussion on the merits of soft nanoarchitectonics based sensing in comparison to conventional analytical methods. Finally, with this Account, we hope to spark new chiral molecule sensing strategies by fundamentally understanding chiral recognition and engineering soft nanoarchitectonics with programmable structures and predictable sensing properties.

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Electrochemical recognition of tryptophan enantiomers using a multi-walled carbon nanotube@polydopamine composite loaded with copper(II)

Cited by 32 publications

References 35 publications

Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan

Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan

Recent progress and future perspectives of polydopamine nanofilms toward functional electrochemical sensors

Soft Nanoarchitectonics for Enantioselective Biosensing

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