Electrochemical sensing of bovine serum albumin at self-assembled SWCNTs on gold

Chen, Yan-Shi; Huang, Jinhua

doi:10.1016/j.diamond.2008.10.022

Cited by 14 publications

(5 citation statements)

References 22 publications

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“…The use of XPS for monitoring and optimizing the electrode assembly process has been explored also in the applications of carbon nanotubes and graphene in electrochemical sensing. Chen et al 39 proposed the use of XPS for the analysis of oxidized MWCNTs functionalized with cysteamine. Such functionalization aimed at allowing the vertical alignment of nanomaterial on a gold surface, thus signicantly increasing the surface/area ratio and consequently enhancing sensor sensitivity.…”

Section: B Monitoring and Optimizing The Stepwise Fabrication Of The ...mentioning

confidence: 99%

XPS in development of chemical sensors

et al. 2015

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Section: B Monitoring and Optimizing The Stepwise Fabrication Of The ...mentioning

confidence: 99%

XPS in development of chemical sensors

et al. 2015

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“…Carbon nanotubes (CNTs) have attracted great attention due to their remarkable electrical, thermal and mechanical properties14 and are a hot topic of much interest in diverse research fields 15–17. The area of CNT–polymer composites has been progressing extremely rapidly in recent years.…”

Section: Introductionmentioning

confidence: 99%

New carbon nanotube–conducting polymer composite electrodes for drug delivery applications

Xiao

et al. 2011

Polymer International

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A novel drug delivery system (DDS) based on a carbon nanotube (CNT)-poly(3,4-ethylenedioxythiophene) (PEDOT) composite was constructed via a layering method. Single-walled CNTs (SWNTs) were immobilized on a gold electrode using a layer-bylayer technique. In particular, cysteamine (Cys) was firstly bonded to the gold surface through the strong S-Au association and SWNTs were subsequently linked onto the Cys layer through condensation reaction of -NH 2 and carboxyl groups by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide coupling. X-ray photoelectron spectroscopy and Raman spectroscopy demonstrate that this is a facile route for immobilizing CNTs on gold electrodes. Finally PEDOT was electropolymerized on the SWNT-functionalized electrode to make a SWNT-PEDOT composite, and the modified electrode was applied as a DDS. Dexamethasone, as a model drug, was incorporated into PEDOT in the electropolymerization. Investigations of the electrochemical properties of SWNT-PEDOT demonstrate that SWNTs greatly improve the conductivity and increase the charge capacity of PEDOT. The composite exhibits a petal-like surface structure, 20-30 nm thick and 100-200 nm wide. Compared to a DDS based on pure PEDOT synthesized under the same conditions, SWNT-PEDOT has the merits of higher drug release rate and larger release amount. The average mass release for every five voltammetry cycles increases from 1.4126 to 1.8864 mg cm −2 .

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“…The carboxyl groups of SWCNT anchored the amino acid groups of BSA in detection and found the detection limit of 1.2 μM. 48 Therefore, the as-prepared DNA@f-BSA/SPE sensor exhibited a good linear dependence between the current and the logarithm of BSA level was achieved with a dynamic working range from 10 -20 g ml −1 to 10 -4 g ml. The detection limit was found to be 2.18 × 10 -21 g ml −1 and the corresponding linear regression equation is I (μA) = 11.4507 + 0.5217C (ng/ml) (R 2 = 0.9984) for BSA.…”

Section: Resultsmentioning

confidence: 95%

Ultrasensitive Detection of Bovine Serum Albumin on DNA Modified Protein Microcapsules-based Electrodes

Dhananjayan¹,

Wilson²,

Gurunathan³

et al. 2023

J. Electrochem. Soc.

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Bovine serum albumin (BSA) emerged as a potential bioprotein in the sensing field. Understanding the interactions of BSA with the analyte biomolecule has not been much reported. Herein, we report the functionally modified BSA (f-BSA) and its consecutive adsorption onto DNA for the ultrasensitive protein sensing. The DNA-modified f-BSA (DNA@f-BSA) composite was further characterized by using scanning electron microscopy, X-ray diffraction, and Fourier transform-infrared spectroscopy. Obtained results demonstrated excellent composite formulation due to electrostatic interaction/binding intercalation and provided promising scaffold for protein biosensor. The as-prepared DNA modified f-BSA (DNA@f-BSA) based biocomposite can be used as a selective probe for the detection of BSA by recording square wave voltammetry signals. The sensitivity of the hybrid biosensor significantly improved the BSA detection over a wide concentration range from 1×10-20 g/mL to 1×10-4 g/mL with a detection limit of 2.18×10-21 g/mL. Thus, the results have revealed the promising biosensor interactions which pave the way for the sensitive protein detection.

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Electrochemical sensing of bovine serum albumin at self-assembled SWCNTs on gold

Cited by 14 publications

References 22 publications

XPS in development of chemical sensors

XPS in development of chemical sensors

New carbon nanotube–conducting polymer composite electrodes for drug delivery applications

Ultrasensitive Detection of Bovine Serum Albumin on DNA Modified Protein Microcapsules-based Electrodes

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