Electrochemical Sensor Arrays

Stefan, Raluca‐Ioana; Staden, Jacobus Frederick van; Aboul‐Enein, Hassan Y.

doi:10.1080/10408349891199293

Cited by 52 publications

(16 citation statements)

References 115 publications

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“…This is one of the reasons why the research on electrochemical arrays has become of recent interest [21]. Examples of application can be found in food, environmental, or clinical analytical chemistry, thanks to advantages such as fast and simple measurements directly in the field, often without any sample pretreatment [22]. A large application of electrochemical arrays can be found also in immunosensor development [23]; in this sense, various immunosensors and immunoassay methods, such as multilabel and spatially resolved assays, have been developed for simultaneous detection of multianalyte [24,25].…”

Section: Magnetic Beads Coupled With Electrochemical Arraymentioning

confidence: 99%

Electrochemical arrays coupled with magnetic separators for immunochemistry

2010

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Electrochemical methods are increasingly applied to immunoassays, because they overcome problems associated with other modes of detection. In particular, with respect to conventional immunoassays, electrochemical immunosensors show versatility, reliability, and fast analysis time. In immunosensor strategy, the antigen or antibody can be immobilized directly onto the surface of the electrochemical transducer that will finally be used to reveal the amount of the affinity reaction. However, the use of the electrode surface as a solid phase as well as an electrochemical transducer presents some problems: a shielding of the surface by biospecifically bound antibody molecules can cause hindrance in the electron transfer, resulting in a reduced voltammetric signal. Thus, as an alternative solid phase, magnetic beads because of their low toxicity and high biocompatibility have gained much attention in chemistry, associated with various analytical techniques, due to their suitability for immobilization of biomolecules. Magnetic micro-or nanobeads can be separated easily and quickly by magnetic forces and will be used together with bioaffine ligands, e.g., antibodies or proteins with a high affinity to the target. The special advantages of magnetic separation techniques are the fast and simple handling of a sample vial and the opportunity to deal with large sample volumes without the need for timeconsuming centrifugation steps. This also makes biomagnetic separation ideal for automated assay/analysis systems which will play a very important role in the near future. This review presents some examples of immunochemical assay developed using magnetic beads as a solid phase coupled with electrochemical detection techniques, in particular, using electrochemical arrays as transducers. Applications related to static measurements, together with in-flow detection systems are presented.

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Section: Magnetic Beads Coupled With Electrochemical Arraymentioning

confidence: 99%

Electrochemical arrays coupled with magnetic separators for immunochemistry

2010

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“…The theoretical background of MSS development and the main signal processing methods were explicitly described in [ 9 , 10 ] more than 10 years ago. The authors presented several methods for processing the data sets obtained by MSSs from gaseous samples: (i) artificial neural network (ANN); (ii) flexible recognition algorithm and (iii) fuzzy logic recognition algorithm.…”

Section: Principles Of Mss and Msamentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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“…Each of the sensing technologies has been assessed individually, although they can be applied in the field as a heterogeneous sensor array or sensor network. In these cases, chemometric data processing applying statistical pattern recognition techniques can be used to identify the unique signature from the joint response of all sensors in the array [16].…”

Section: Assessment Of Relevant Chemical Sensing Technologiesmentioning

confidence: 99%