Electrochemical Sensor for Rapid and Sensitive Detection of Tryptophan by a Cu2O Nanoparticles-Coated Reduced Graphene Oxide Nanocomposite

He, Quanguo; Tian, Yaling; Wu, Yiyong; Liu, Jun; Li, Guangli; Deng, Peihong; Chen, Dongchu

doi:10.3390/biom9050176

Cited by 110 publications

(48 citation statements)

References 52 publications

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“…This wrinkled nature of GR is highly beneficial in maintaining a high surface area on the electrode since the sheets cannot readily collapse back to a graphitic structure [ 32 ]. Most importantly, it could indicate that the dispersity of PVP-GR composite was much better, which was extremely essential for nanomaterials dispersed in solution and for their further application [ 33 ]. Therefore, it is greatly expected that the performance of the sensor is improved by the PVP-GR composite.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite

Wu¹,

Deng²,

Tian³

et al. 2020

J Nanobiotechnol

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177

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A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, which based on the polyvinylpyrrolidone (PVP)-graphene composite film modified glassy carbon electrode (PVP-GR/GCE), was presented for detecting ascorbic acid (AA), dopamine (DA) and uric acid (UA) simultaneously. The PVP-GR/GCE has excellent electrocatalytic activity for the oxidation of AA, DA and UA. The second-order derivative linear sweep voltammetry was used for the electrochemical measurements. The peak potential differences of DA-AA, DA-UA, and UA-AA (measured on the PVP-GR/GCE) were 212, 130 and 342 mV respectively. Besides, the over potential of AA, DA and UA reduced obviously, so did the peak current increase. Under the optimum conditions, the linear ranges of AA, DA and UA were 4.0 μM-1.0 mM, 0.02-100 μM, and 0.04-100 μM, respectively. The detection limits were 0.8 μM, 0.002 μM and 0.02 μM for AA, DA, and UA. The electrochemical sensor presented the advantages of high sensitivity and selectivity, excellent reproducibility and long-term stability. Furthermore, the sensor was successfully applied to the analysis of real samples.

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Section: Resultsmentioning

confidence: 99%

Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite

Wu¹,

Deng²,

Tian³

et al. 2020

J Nanobiotechnol

Self Cite

177

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“…The organic functionalization and inorganic nanoparticles attachments on the surface of GR significantly changed the physical and chemical properties of GR and greatly expanded its application field [ 20 , 21 , 22 , 23 , 24 ]. Recently, lots of researches have been carried out to modify the surface of GR with MnO 2 [ 25 , 26 ], SnO 2 [ 27 ], Fe 3 O 4 [ 28 , 29 ], Co 3 O 4 [ 30 ], Cu 2 O [ 31 , 32 , 33 ], NiO [ 34 ], TiO 2 [ 35 ], and other metal oxide nanoparticles, and to find their applications in electrode modification. CeO 2 nanoparticles have the advantages of low cost, excellent electrochemical redox characteristic, and environmental friendliness, and are explored as an excellent electrode modifier material [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication of CeO2/Electrochemically Reduced Graphene Oxide Nanocomposites for Vanillin Detection in Commercial Food Products

et al. 2020

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In this paper, CeO2 nanoparticles were synthesized by the solvothermal method and dispersed uniformly in graphene oxide (GO) aqueous solution by ultrasonication. The homogeneous CeO2-GO dispersion was coated on the surface of a glassy carbon electrode (GCE), and the CeO2/electrochemically reduced graphene oxide modified electrode (CeO2/ERGO/GCE) was obtained by potentiostatic reduction. The results of X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) showed that CeO2 nanocrystals were uniformly coated by gossamer like ERGO nanosheets. The electrochemical behavior of vanillin on the CeO2/ERGO/GCE was studied by cyclic voltammetry (CV). It was found that the CeO2/ERGO/GCE has high electrocatalytic activity and good electrochemical performance for vanillin oxidation. Using the second derivative linear sweep voltammetry (SDLSV), the CeO2/ERGO/GCE provides a wide range of 0.04–20 µM and 20 µM–100 µM for vanillin detection, and the detection limit is estimated to be 0.01 µM after 120 s accumulation. This method has been successfully applied to the vanillin detection in some commercial foods.

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“…To explore the practical application of MIP/ABPE, it was used to determine Trp in human serum samples and compound amino acid injections. A serum sample solution was prepared according to our previous report [11,49,50,51,52]. The compound amino acid injection was diluted 100 times with distilled water and used directly.…”

Section: Resultsmentioning

confidence: 99%

A Simple and Efficient Molecularly Imprinted Electrochemical Sensor for the Selective Determination of Tryptophan

Tian

Deng

et al. 2019

Biomolecules

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In this paper, a tryptophan (Trp) molecularly imprinted chitosan film was prepared on the surface of an acetylene black paste electrode using chitosan as the functional polymer, Trp as the template molecule and sulfuric acid as the crosslinking agent. The surface morphologies of non-imprinted and imprinted electrodes were characterized by scanning electron microscopy (SEM). The formation of hydrogen bonds between the functional polymer and the template molecule was confirmed by infrared spectroscopy. Some factors affecting the performance of the imprinted electrode such as the concentration of chitosan, the mass ratio of chitosan to Trp, the dropping amount of the chitosan-Trp mixture, the solution pH, and the accumulation potential and time were discussed. The experimental results show that the imprinted electrode exhibit good affinity and selectivity for Trp. The dynamic linear ranges of 0.01–4 M, 4–20 M and 20–100 M were obtained by second derivative linear sweep voltammetry, and the detection limit was calculated to be 8.0 nM. The use of the imprinted electrode provides an effective method for eliminating the interference of potentially interfering substances. In addition, the sensor has high sensitivity, reproducibility and stability, and can be used for the determination of Trp in pharmaceutical preparations and human serum samples.

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Electrochemical Sensor for Rapid and Sensitive Detection of Tryptophan by a Cu2O Nanoparticles-Coated Reduced Graphene Oxide Nanocomposite

Cited by 110 publications

References 52 publications

Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite

Simultaneous and sensitive determination of ascorbic acid, dopamine and uric acid via an electrochemical sensor based on PVP-graphene composite

Facile Fabrication of CeO2/Electrochemically Reduced Graphene Oxide Nanocomposites for Vanillin Detection in Commercial Food Products

A Simple and Efficient Molecularly Imprinted Electrochemical Sensor for the Selective Determination of Tryptophan

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