Electrochemical skin conductance for quantitative assessment of sweat function: Normative values in children

Leclair‐Visonneau, Laurène; Bosquet, Tristan; Magot, Armelle; Fayet, Guy; Guen, C. Gras-Le; Hamel, Antoine; Péreón, Yann

doi:10.1016/j.cnp.2016.07.001

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…[ 23 ] In a previous study, ESC measurements in healthy children were found to be similar to those observed in healthy adults. [ 24 ] Good reproducibility has been reported between two sequential measurements performed at rest, and there is no significant variation in ESC after exercise. [ 13 25 ] These advantages make ESC an attractive option for large-scale screening and intervention trials.…”

Section: Discussionmentioning

confidence: 99%

Normative values for electrochemical skin conductance measurements for quantitative assessment of sudomotor function in healthy Indian adults

Shivaprasad

Goel

Vilier

et al. 2018

Indian J Endocr Metab

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Context:Electrochemical skin conductance (ESC) test is a widely accepted objective technique for quantitatively assessing sudomotor dysfunction, which is one of the earliest-detected neurophysiologic abnormalities in diabetic patients with distal symmetric polyneuropathy.Aims:This study aimed to provide normative data for ESC values among healthy Indian participants and assess the potential influence of age, sex, and body mass index (BMI) on ESC measurements.Settings and Design:A sample of 217 healthy participants aged 18–75 years were recruited and assessed for parameters including age, gender, BMI, and ESC measurements of the hands and feet.Statistical Analysis Used:The Shapiro–Wilk test was used to assess the normality of the data. Pearson's correlation was used to evaluate the association between age, gender, and BMI, and ESC measurements.Results:The mean age of the participants was 43.3 ± 13.2 years, and mean BMI was 26.0 ± 4.3 kg/m2. Mean ESC for the hands and feet was 68.9 ± 13.1 and 71 ± 12.9 micro-Siemens, respectively, and there was a significant correlation between values from the right and left hands and feet (r = 0.9, P < 0.0001). A significant correlation was also observed between ESC measurements of the hands and feet (r = 0.94, P < 0.0001). ESC values of both hands and feet declined with age. A weak but significant inverse correlation between ESC and age was observed for the hands (r = 0.02, P = 0.01) and for the feet (r = 0.12, P < 0.0001). There was no significant difference in hand or feet ESC measurement between male and female participants. No significant correlation was observed between BMI and ESC of hands or feet. Only age was identified as a significant determinant of ESC on multivariate logistic regression analysis.Conclusions:Normative values for Indians are lower than that reported for Caucasians.

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Section: Discussionmentioning

confidence: 99%

Normative values for electrochemical skin conductance measurements for quantitative assessment of sudomotor function in healthy Indian adults

Shivaprasad

Goel

Vilier

et al. 2018

Indian J Endocr Metab

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“…The small sex parameter (~ 0-3) is considered as non relevant for clinical applications and our last model integrating the daily and annual variations also tends to make this effect mostly null. The age parameter was estimated to -0.12 in clinical study, and here around -0.2 3,14,15,17 Although we probably did not filter out all the non-healthy users and we have no information about ethnicity, which is another important confounder of ESC normal values 14,15,17,18 , we can consider that the effect of age should be between -0.1 and -0.2 per year. Thus, the ESC value is reduced by 1 to 2 points per decade for each individual, which should not be neglected in the clinical monitoring of patients at advanced ages to determine the possible evolution of a peripheral neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Chronobiological, age and sex effects on Electrochemical Skin Conductance: results from a large observational data set

Vittrant,

Courrier,

Mauries

et al. 2024

Preprint

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This study presents a comprehensive analysis of electrochemical skin conductance (ESC) values collected from over 1.9 million measurements using Withings Body Scan and Body Comp scales. Aimed at establishing normative values for ESC, this research incorporates a large, global dataset to explore the influence of age, sex, and circadian and seasonal variations on sudomotor function. Our findings reveal that ESC values exhibit a small, gradual decline with age and are potentially slightly lower in women compared to men. Notably, we identified significant daily and annual patterns in ESC values, suggesting the influence of chronobiological factors. By employing both univariate and multivariate regression models, including an approach using sinusoidal variations, we refined our understanding of these patterns. The study underscores the importance of considering these variations in clinical and home monitoring of ESC, offering new insights into peripheral neuronal aging and the potential for ESC as a biomarker for sympathetic and parasympathetic nervous system balance. Our work establishes a crucial reference for interpreting ESC measurements, taking into account demographic, biological, and seasonal variations, and highlights the need for further research to explore the clinical implications of these findings.

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“…The Quantitative Sudomotor Axon Reflex Test (QSART) is a sensitive and reproducible test of sudomotor function, but is limited by cost and extensive patient preparation time [ 15 , 16 ]. Since electrochemical skin conductance (ESC) depends on sweat gland function [ 17 ], its values may quantify sudomotor function and provide a surrogate marker for autonomic neuropathy. Sudoscan has been developed as a method to measure ESC, with preliminary findings suggesting its potential use as a measure of small nerve fibre function across disorders, such as diabetic peripheral neuropathy [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients

Mahfouz

Park

et al. 2022

Clin Auton Res

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Purpose Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse event of cancer treatment that can affect sensory, motor, or autonomic nerves. Assessment of autonomic neuropathy is challenging, with limited available tools. Accordingly, it is not routinely assessed in chemotherapy-treated patients. In this study, we aimed to examine whether electrochemical skin conductance (ESC) via Sudoscan, a potential measure of autonomic function, associates with subjective and objective measures of CIPN severity and autonomic neuropathy. Methods A cross-sectional assessment of patients who completed neurotoxic chemotherapy 3–24 months prior was undertaken using CIPN patient-reported outcomes (EORTC-QLQ-CIPN20), clinically graded scale (NCI-CTCAE), neurological examination score (TNSc), autonomic outcome measure (SAS), and Sudoscan. Differences in CIPN severity between participants with or without ESC dysfunction were investigated. Linear regression analyses were used to identify whether ESC values could predict CIPN severity. Results A total of 130 participants were assessed, with 93 participants classified with CIPN according to the clinically graded scale (NCI-CTCAE/grade ≥ 1), while 49% demonstrated hands or feet ESC dysfunction (n = 46). Participants with ESC dysfunction did not significantly differ from those with no dysfunction on multiple CIPN severity measures (clinical-grade, patient-report, neurological examination), and no differences on the autonomic outcome measure (SAS) (all p > 0.0063). Linear regression analyses showed that CIPN could not be predicted by ESC values. Conclusions The inability of ESC values via Sudoscan to predict clinically-graded and patient-reported CIPN or autonomic dysfunction questions its clinical utility for chemotherapy-treated patients. The understanding of autonomic neuropathy with chemotherapy treatment remains limited and must be addressed to improve quality of life in cancer survivors.

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Electrochemical skin conductance for quantitative assessment of sweat function: Normative values in children

Abstract: HighlightsSudomotor function can be assessed through the measurement of electrochemical skin conductance using the Sudoscan system.This test is easily done in children and normative data are provided.It can be helpful in case of small fibre neuropathy in children.

Cited by 11 publications

References 5 publications

Normative values for electrochemical skin conductance measurements for quantitative assessment of sudomotor function in healthy Indian adults

Normative values for electrochemical skin conductance measurements for quantitative assessment of sudomotor function in healthy Indian adults

Chronobiological, age and sex effects on Electrochemical Skin Conductance: results from a large observational data set

Association of electrochemical skin conductance with neuropathy in chemotherapy-treated patients

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