Electrochemical Synthesis of Amino Derivatives of Biflavonoids

Nadirov, Rashid; Надиров, К. С.; Esimova, A. M.; Nadirova, Zh. K.

doi:10.1007/s10600-014-1067-9

Cited by 7 publications

(9 citation statements)

References 4 publications

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“…Once the electrolysis was completed, about 90% of the acetonitrile was distilled from the anode compartment. Further purification using chromatography column was applied and followed by recrystallization to obtain the biflavonoid product with a good yield (60–70%) [82] .…”

Section: Synthetic Sourcesmentioning

confidence: 99%

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus

Hartini¹,

Saputra²,

Wahono³

et al. 2021

Results in Chemistry

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Section: Synthetic Sourcesmentioning

confidence: 99%

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus

Hartini¹,

Saputra²,

Wahono³

et al. 2021

Results in Chemistry

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“…The lack of high speeds inside the screw pumps makes them promising for use as dredging pumps that drain rainwater into the collection network [11][12][13][14]. However, these pumps have not been widely used in the sewer industry [15][16][17][18][19]. This is due to the fact that traditional designs of screw pumps have a number of disadvantages that hinder their widespread adoption [20].…”

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confidence: 99%

“…The installation will make possible to change the angle of inclination of the screw a, its rotation frequency n, water level in the channel in front of the screw, as well as the gap between the screw and the tray in which it rotates . It is known that the total pump efficiency η povn consists of its mechanical η mex , hydraulic η gidr and volumetric efficiency η obemn and is determined by the equation ( 16) (16) Mechanical efficiency depends on the design of the pump. In the experimental setup, an electric drive with a single-stage reduction unit is used.…”

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confidence: 99%

A Model for Calculating the Collection and Pumping of Rain and Melt Water in the Design of Multifunctional Buildings for Public and Industrial Purposes

Jakovlevs¹

2021

News of NAN RK. SGTS

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In drainage systems, it is often necessary to raise polluted rain and melt water to a low height. For example, pumping wastewater from one gravity collector to another, raising wastewater by several meters in order to reduce the deepening of the collecting sewer collector and, as a result, reduce capital costs for its construction. In such places, it may be more economically feasible to reduce such deepening. The novelty of the study is that the development of a drain can be fulfilled only if the filling of the throughput of the collectors is sufficiently ensured. The study shows that the possibilities of expanding collectors can be achieved based on compensation for energy consumption. The study outlined the necessity of allocating the device of a high-pressure pumping station with the subsequent laying of a pressure sewage collector to a common collector, or to the main sewer network, which in turn supplies rain and melt water to the main collector. The practical significance of the study is the widespread introduction of intermediate pumps of low pressure in sewerage networks is constrained by the lack of a sufficient range of reliable and economical low pressure pumps for contaminated liquids.

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“…However, known methods for synthesizing flavopiridol analogs [2, 3] are complicated and multi-step. Therefore, the successful electrochemical synthesis of biflavonoids and their N-containing analogs [4,5] allowed us to propose that it can be used to synthesize new flavopiridol analogs.Chrysine (0.254 g, 1 mmol, Aldrich) was dissolved in MeCN (250 mL), treated with LiClO 4 (0.110 g) and morpholine (0.520 mL), and electrolyzed in a diaphragm cell at a Pt anode with a working surface of 2 cm 2 and current 12 mA. KCl (0.5 g) was mixed with the anode liquor after 3 h of electrolysis, which then was continued for 2.5 h. When the electrolysis was finished, about 90% of the solvent was distilled from the anode liquor.…”

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confidence: 99%

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confidence: 99%

Synthesis and Cytotoxic Activity of New Flavopiridol Analogs

et al. 2016

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Structural analogs of flavopiridol {2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone} are attractive as potential antitumor drugs [1]. They can be represented as a chrysine flavonoid in which the C22 H is replaced by Cl; the C8 H, by a N-containing heterocycle (3-hydroxy-N-methylpiperidine in the case of flavopiridol). However, known methods for synthesizing flavopiridol analogs [2, 3] are complicated and multi-step. Therefore, the successful electrochemical synthesis of biflavonoids and their N-containing analogs [4,5] allowed us to propose that it can be used to synthesize new flavopiridol analogs.Chrysine (0.254 g, 1 mmol, Aldrich) was dissolved in MeCN (250 mL), treated with LiClO 4 (0.110 g) and morpholine (0.520 mL), and electrolyzed in a diaphragm cell at a Pt anode with a working surface of 2 cm 2 and current 12 mA. KCl (0.5 g) was mixed with the anode liquor after 3 h of electrolysis, which then was continued for 2.5 h. When the electrolysis was finished, about 90% of the solvent was distilled from the anode liquor. Two red pure compounds were isolated from the residual by column chromatography (Porokvarts PKN-200, CHCl 3 -EtOH, 80:20 v/v, 5 mL/min).The yields of 1 and 2 calculated for starting chrysine were (0.17 ± 0.01 g, 45.2 ± 1.5%) and (0.13 ± 0.01 g, 34.6 ± 1.5%), respectively. 5,7-Dihydroxy-8-morpholino-2-(2-chlorophenyl)-4H-chromen-4-one (1). C 19 H 16 NO 5 Cl, mp 241 r 3qÑ, [D] D 20 +52.7q (c 0.35, MeOH). UV spectrum (MeOH, O max , nm): 210, 305, 346. IR spectrum (KBr, Q max , cm -1 ): 3615, 3340

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Electrochemical Synthesis of Amino Derivatives of Biflavonoids

Cited by 7 publications

References 4 publications

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus

A Model for Calculating the Collection and Pumping of Rain and Melt Water in the Design of Multifunctional Buildings for Public and Industrial Purposes

Synthesis and Cytotoxic Activity of New Flavopiridol Analogs

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