Electrochemical technique to develop surface-controlled polyaniline nano-tulips (PANINTs) on PCL-reinforced chitosan functionalized (CS-f-Fe2O3) scaffolds for stimulating osteoporotic bone regeneration

Ghimire, Upasana; Kandel, Rupesh; Ko, Sung Won; Adhikari, Jhalak Raj; Kim, Cheol Sang; Park, Chan Hee

doi:10.1016/j.ijbiomac.2024.130608

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.130608

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Electrochemical technique to develop surface-controlled polyaniline nano-tulips (PANINTs) on PCL-reinforced chitosan functionalized (CS-f-Fe2O3) scaffolds for stimulating osteoporotic bone regeneration

Upasana Ghimire,

Rupesh Kandel,

Sung Won Ko

et al.

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2024

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Cited by 2 publications

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Conjugated Matrix Nanocomposites with Nanodiamond Nanoadditives—Fundamentals and Forefronts

Kausar

2024

Journal of Macromolecular Science, Part B

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Conjugated Matrix Nanocomposites with Nanodiamond Nanoadditives—Fundamentals and Forefronts

Kausar

2024

Journal of Macromolecular Science, Part B

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Alendronate Functionalized Bone-Targeting Pomolic Acid Liposomes Restore Bone Homeostasis for Osteoporosis Treatment

Xia,

Qian,

Wang

et al. 2024

IJN

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Introduction:Osteoporosis, characterized by dysregulation of osteoclastic bone resorption and osteoblastic bone formation, severely threatens human health during aging. However, there is still no good therapy for osteoporosis, so this direction requires our continuous attention, and there is an urgent need for new drugs to solve this problem. Methods: Traditional Chinese Medicine Salvia divinorum monomer pomolic acid (PA) could effectively inhibit osteoclastogenesis and ovariectomized osteoporosis. However, its poor solubility and lack of targeting severely limits its further application. A novel bone-targeting nanomedicine (PA@TLipo) has been developed to reconstruct the osteoporotic microenvironment by encapsulating pomolic acid in alendronate-functionalized liposomes. Through a series of operations such as synthesis, purification, encapsulation, and labeling, the PA@TLipo have been prepared. Moreover, the cytotoxicity, bone targeting and anti-osteoporosis effect was verified by cell and animal experiments. Results: In the aspect of targeting, the PA@TLipo can effectively aggregate on the bone tissue to reduce bone loss, and in terms of toxicity, PA@TLipo could increase the bone target ability in comparison to nontargeted liposome, thereby mitigating systemic cytotoxicity. Moreover, PA@TLipo inhibited osteoclast formation and bone resorption in vitro and reduced bone loss in ovariectomyinduced osteoporotic mice. Conclusion:In this study, a novel therapeutic agent was designed and constructed to treat osteoporosis, consisting of a liposome material as the drug pocket, PA as the anti-osteoporosis drug, and ALN as the bone-targeting molecule. And our study is the first to employ a bone-targeted delivery system to deliver PA for OVX-induced bone loss, providing an innovative solution for treating osteoporosis.

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Electrochemical technique to develop surface-controlled polyaniline nano-tulips (PANINTs) on PCL-reinforced chitosan functionalized (CS-f-Fe2O3) scaffolds for stimulating osteoporotic bone regeneration

Cited by 2 publications

References 52 publications

Conjugated Matrix Nanocomposites with Nanodiamond Nanoadditives—Fundamentals and Forefronts

Conjugated Matrix Nanocomposites with Nanodiamond Nanoadditives—Fundamentals and Forefronts

Alendronate Functionalized Bone-Targeting Pomolic Acid Liposomes Restore Bone Homeostasis for Osteoporosis Treatment

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