Electrochemical treatment of tumors using a one-probe two-electrode device

Olaiz, Nahuel Manuel; Maglietti, Felipe Horacio; Suárez, Cecilia; Molina, Fernando V.; Miklavčič, Damijan; Mir, Lluis M.; Marshall, Guillermo

doi:10.1016/j.electacta.2010.05.057

Cited by 26 publications

(16 citation statements)

References 13 publications

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“…The appropriate placement of the electrodes inside or on the periphery of the tumor is thus a crucial parameter for the success of the treatment. New electrode systems containing one probe associated to two electrodes have been recently developed [Olaiz et al, 2010]. EChT is not suited for the treatment of tumors close to major veins or arteries as it can entail thrombosis [Metcalfe et al, 2007].…”

Section: Electrochemical Treatment Of Cancermentioning

confidence: 99%

Microsecond and nanosecond electric pulses in cancer treatments

Breton¹,

Mir²

2011

Bioelectromagnetics

184

133

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New local treatments based on electromagnetic fields have been developed as non-surgical and minimally invasive treatments of tumors. In particular, short electric pulses can induce important non-thermal changes in cell physiology, especially the permeabilization of the cell membrane. The aim of this review is to summarize the present data on the electroporation-based techniques: electrochemotherapy (ECT), nanosecond pulsed electric fields (nsPEFs), and irreversible electroporation (IRE). ECT is a safe, easy, and efficient technique for the treatment of solid tumors that uses cell-permeabilizing electrical pulses to enhance the activity of a non-permeant (bleomycin) or low permeant (cisplatin) anticancer drug with a very high intrinsic cytotoxicity. The most interesting feature of ECT is its unique ability to selectively kill tumor cells without harming normal surrounding tissue. ECT is already used widely in the clinics in Europe. nsPEFs could represent a drug free, purely electrical cancer therapy. They allow the inhibition of tumor growth, and interestingly, nsPEF can target intracellular organelles. However, many questions remain on the mechanism of action of these pulses. Finally, IRE is a new ablation procedure using pulses that provoke the permanent permeabilization of the cells resulting in their death. This technique does not result in any thermal effect, which is its main advantage in current physical ablation technologies. For both the nsPEF and the IRE, the preservation of the normal tissue, which is characteristic of ECT, has not yet been shown and their safety and efficacy still have to be investigated thoroughly in vivo and in the clinics.

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Section: Electrochemical Treatment Of Cancermentioning

confidence: 99%

Microsecond and nanosecond electric pulses in cancer treatments

Breton¹,

Mir²

2011

Bioelectromagnetics

184

133

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“…In a previous paper [39] we looked into the electroporation process from a new angle apparently overseen in the literature, the role of pH in ECT modeling based on ion transport during the treatment. The analysis was developed through in vitro gel measurements and theoretical modeling drawing from previous experience in the electrochemical treatment of tumors (EChT, another electrochemical-based antitumoral treatment that uses constant electric fields with the aim of eliminating tumors mainly by necrosis, see for instance [39] – [43] , [58] ) and in electrochemical deposition in thin layer cells [44] . It is well known that, during EChT, two opposing pH fronts emerge from both electrodes (acid from the anode and basic from the cathode) until there is a collision somewhere between them.…”

Section: Introductionmentioning

confidence: 99%

The Role of Ph Fronts in Tissue Electroporation Based Treatments

et al. 2013

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Treatments based on electroporation (EP) induce the formation of pores in cell membranes due to the application of pulsed electric fields. We present experimental evidence of the existence of pH fronts emerging from both electrodes during treatments based on tissue EP, for conditions found in many studies, and that these fronts are immediate and substantial. pH fronts are indirectly measured through the evanescence time (ET), defined as the time required for the tissue buffer to neutralize them. The ET was measured through a pH indicator imaged at a series of time intervals using a four-cluster hard fuzzy-c-means algorithm to segment pixels corresponding to the pH indicator at every frame. The ET was calculated as the time during which the number of pixels was 10% of those in the initial frame. While in EP-based treatments such as reversible (ECT) and irreversible electroporation (IRE) the ET is very short (though enough to cause minor injuries) due to electric pulse characteristics and biological buffers present in the tissue, in gene electrotransfer (GET), ET is much longer, enough to denaturate plasmids and produce cell damage. When any of the electric pulse parameters is doubled or tripled the ET grows and, remarkably, when any of the pulse parameters in GET is halved, the ET drops significantly. Reducing pH fronts has relevant implications for GET treatment efficiency, due to a substantial reduction of plasmid damage and cell loss.

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“…Это обстоятельство, на наш взгляд, объясняет разнообразие конфигураций используемых электродов, а, следовательно, и различия в получаемых результатах [16,27]. Возможным решением представляется использование математического моделирования дозы, распределения электрического поля и плотности электрического тока в опухоли и окружающей ткани [34,36,37]. Существующие математические модели ЭХЛ в терапии опухолей применяются крайне редко и нуждаются в оптимизации.…”

Section: Discussionunclassified

Electrochemical Lysis in Oncology: Literature Review

et al. 2021

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Recently, minimally invasive treatment modalities based on the application of various physical factors have been widely used in anticancer therapy. Electrochemical lysis is a method in which tumor cells are destroyed by local exposure to a constant low voltage electric current.Purpose: to present the current results of using electrochemical lysis in the treatment of various tumors, to describe the mechanism of tumor destruction and methods of delivering electric current to the tumor, as well as to evaluate the electrical parameters and positioning of the electrodes.Material and Methods.aliterature search included the Medical literatureanalysis and Retrieval system Online (Medline), the excerpta Medica data Base (embase), Web of science, scopus, Russian citation index. All articles were published before december 2019. The review included studies on the investigation electrochemical lysis in vitro, in vivo, as well as clinical observations and clinical studies in which electrochemical lysis has been used as an independent treatment, or in combination with other methods of anticancer treatment since 1984.Results. This review provides information regarding the electrochemical mechanisms of tumor destruction, anti-tumoral effects of electrochemical therapy, methodology for planning and distributing the dose of electrical lysis and positioning of electrodes. We have evaluated complications and oncological results. Electrochemical lysis is a safe, simple, effective, and relatively non-invasive method of antitumor treatment.Conclusion. The electrochemical lysis is a promising minimally invasive method which can be used for the treatment of tumors. However, long-term data are needed to validate this treatment before it can be included into clinical recommendation for the treatment of cancer patients.

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Electrochemical treatment of tumors using a one-probe two-electrode device

Cited by 26 publications

References 13 publications

Microsecond and nanosecond electric pulses in cancer treatments

Microsecond and nanosecond electric pulses in cancer treatments

The Role of Ph Fronts in Tissue Electroporation Based Treatments

Electrochemical Lysis in Oncology: Literature Review

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