Electrochemical treatment of tumours

Nilsson, Eva; Euler, Henrik von; Berendson, Jaak; Thörne, A.; Wersäll, Peter; Näslund, Ingemar; Lagerstedt, Anne-Sofie; Narfström, Kristina; Olsson, Jerker M.

doi:10.1016/s0302-4598(99)00073-2

Cited by 118 publications

(127 citation statements)

References 43 publications

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“…The electric field itself and the resultant extreme local pH changes influence both survival and proliferation of the cells, causing unphysiological conditions, responsible for the modification of the ion exchange across the cell membranes and vital protein denaturation. 14 The choice of anode material determines the electrode reactions at the anode. If the anode material is electrochemically soluble, the major part of the anodic current will consist of metal dissolution.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

“…The electrode potential obtained will therefore dictate which species can be oxidised or reduced, at the electrode surface. 14 The choice of cathode material is less crucial than the choice of anode, since the cathode is generally more stable and the main reaction is quite exclusively water decomposition into hydrogen and hydroxyl ions. 14 The anodic current density is a very important parameter.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

“…14 The choice of cathode material is less crucial than the choice of anode, since the cathode is generally more stable and the main reaction is quite exclusively water decomposition into hydrogen and hydroxyl ions. 14 The anodic current density is a very important parameter. Different destructive effects are obtained depending on the magnitude of current density used during the treatment.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

“…Several field configurations have been tried. 14 The anode is preferably placed in the tumour and the cathode in a blood vessel or in a fresh surrounding tissue. 14 Scheme 1.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

“…12 Mathematical models of these processes were developed and showed to be powerful tools in establishing a reliable dosage method, with the prediction of the tumour destruction produced through EchT. 14 Concentration profiles of substances dissolved in tissue and the potential profile within the tissue itself can be simulated as a function of time.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

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Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Abreu¹,

Ferraz²,

Goulart³

2002

J. Braz. Chem. Soc.

154

124

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Essa revisão resume alguns dos aspectos mais relevantes na correlação entre processos e parâmetros eletroquímicos e atividades biológicas, relacionadas, principalmente, a doenças tropicais e câncer. Apesar da gama de possibilidades e da complexidade da química celular/tecidual/extracelular, é possível racionalizar o papel da eletroquímica em poucas bases teóricas, principalmente: transferência eletrônica -estresse oxidativo, geração eletroquímica in situ de agentes tóxicos diferentes das espécies oxigenadas reativas, interação com endobióticos, com ênfase particular em alquilação biorredutiva e substituição de endobióticos com função em reações de oxi-redução biológicas. O uso de métodos eletroquímicos para a obtenção de mecanismos de ação de drogas e na análise de eventos celulares é também apresentado. Nessas correlações, métodos e/ou parâmetros eletroquímicos exercem papel relevante, porém, não absoluto.This review summarises some of the more relevant achievements in the correlation between electrochemical processes and parameters and bioactive properties, mainly related to cancer and tropical diseases. Despite the broad range of possibilities and the complexity of cell/tissue/extracell chemistry, it is possible to rationalise the role of electrochemistry in few basic theoretical frameworks, mainly, the one based on electron transfer-oxidative stress and in situ generation of toxic species, other than the reactive oxygen species; interaction with endobiotics, with emphasis on bioreductive alkylation and replacement of endobiotics with function in biological redox reactions. The use of electrochemical methods to obtain relevant informations about drugs' mechanism of action and analysis of cellular events is also presented. Electrochemical methods and/or parameters play essential but not absolute roles.

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Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

“…Several field configurations have been tried. 14 The anode is preferably placed in the tumour and the cathode in a blood vessel or in a fresh surrounding tissue. 14 Scheme 1.…”

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

Section: The Electrochemical Treatment Of Tumoursmentioning

confidence: 99%

See 3 more Smart Citations

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Abreu¹,

Ferraz²,

Goulart³

2002

J. Braz. Chem. Soc.

154

124

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Liquid Metal for Biomedicine

2022

Liquid Metals

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Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

et al. 2019

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Electrochemical therapy (EChT), by inserting electrodes directly into tumors to kill cancer cells under direct current (DC), is clinically used in several countries. In EChT, the drastic pH variation nearby the inserted electrodes is the main cause of tumor damage. However, its limited effective area and complex electrode configuration have hindered the clinical application of EChT in treating diverse tumor types. Herein, a conceptually new electric cancer treatment approach is presented through an electro‐driven catalytic reaction with platinum nanoparticles (PtNPs) under a square‐wave alternating current (AC). The electric current triggers a reaction between water molecules and chloride ions on the surface of the PtNPs, generating cytotoxic hydroxyl radicals. Such a mechanism, called electrodynamic therapy (EDT), enables effective killing of cancer cells within the whole electric field, in contrast to EChT, which is limited to areas nearby electrodes. Remarkable tumor destruction efficacy is further demonstrated in this in vivo EDT treatment with PtNPs. Therefore, this study presents a new type of cancer therapy strategy with a tumor‐killing mechanism different from existing methods, using nanoparticles with electrocatalytic functions. This EDT method appears to be minimally invasive, and is able to offer homogeneous killing effects to the entire tumor with a relatively large size.

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Electrochemical treatment of tumours

Cited by 118 publications

References 43 publications

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Some Applications of Electrochemistry in Biomedical Chemistry. Emphasis on the Correlation of Electrochemical and Bioactive Properties

Liquid Metal for Biomedicine

Platinum Nanoparticles to Enable Electrodynamic Therapy for Effective Cancer Treatment

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