Electrochemical Trifluoromethylthiolation/Cyclization of N-Arylacrylamides with AgSCF₃: Access to SCF₃-Containing Oxindoles

Abstract

An environmentally friendly electrochemical strategy for the synthesis of SCF 3 -containing oxindoles was developed. This electrochemical transformation was accomplished through a cascade trifluoromethylthiolation/cyclization of N-acrylamides with AgSCF 3 , obviating the requirement for external oxidants. A variety of functional groups were well tolerated in this transformation.