Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dualfunctionalized graphene substrate

Abstract

Here we report a dual-functionalized electrochemical substrate to trigger cancer cells release based on the supramolecular interaction between β-cyclodextrin (β-CD) and Fc on clinical trial II aptamer AS1411 functionalized graphene platform. On one hand, the host-guest interaction can be reversible electrochemically controlled to realize cancer cells capture/release, and 1-adamantylamine binding can further amplify this surface change by competing interaction with β-CD. On the other hand, the AS1411 aptamer and its complementary DNA (cDNA) also can be used as a switchable anchor for cell adhesion. Our work gives an example for label-free, multi-functionalized triggered cell release based on aptamer and β-CD/graphene-modified surface and this multi-ways for cell catch-and-release on graphene modified surface also provides their potential biomedical application.

Dual Responsive Surfaces Based on Host–Guest Interaction for Dynamic Mediation of Cell–Substrate Interaction and Cell Migration

“…Therefore, the UV radiation time was fixed at 5 min in all the following experiments. The combination of Ama competition and UV irradiation could lead to even more release of the azo‐REDV (Figure a), indicating the synergetic effect as also observed previously …”

Highly sensitive and simultaneous electrochemical determination of 2-aminophenol and 4-aminophenol based on poly( l -arginine)-β-cyclodextrin/carbon nanotubes@graphene nanoribbons modified electrode

“…It is noted that the fitted charge transfer resistance (R ct ) value of the P-β-CD-L-Arg/GCE is a little larger than that of the bare GCE, suggesting that the electron transfer of the electrochemical probe Fe(CN) 6 3-/4-on the P-β-CD-L-Arg/GCE is obstructed due to the poor electronic conductivity of P-β-CD. (Feng et al, 2015;Wei et al, 2011) However, the R ct value of P-β-CD-L-Arg/CNTs@GNRs/GCE is dramatically decreased, implying that the CNTs@GNRs could show prominent electrochemical properties for effectively enhancing the conductivity of modified electrode and promoting electron transfer.…”

Recent Advances in Cyclodextrin‐Based Light‐Responsive Supramolecular Systems

“…Mixing two kinds of polymers with pendant CD molecules and the guest molecules separately generates s gel . CD‐modified substrates as well as cell membranes can specifically capture and release small molecules, biomacromolecules, nanoparticles, cells, etc . The inclusion complex as nanovalves closes the nanopores of inorganic nanoparticles (e.g., mesoporous silica nanoparticles) to enhance the effective release of the cargo .…”