Electrochemically assisted SERS sensing of adenosine triphosphate using a carbon microelectrode with composite plasmonic nanostructures

SERS microscopy as a tool for comprehensive biochemical characterization in complex samples

“…the synthesis of silver nanostructures in the presence of bacteria 38 and plant samples 39 or the electrochemical incorporation of the analyte into plasmonic nanostructures from their biological environment. 40 The application of an electric potential in order to direct molecules towards the SERS active structure has proven as useful concept. Often, microelectrodes are used to yield the preferred interaction of molecules in complex mixtures that otherwise would escape an analysis, can provide additional enrichment 41 or guide molecules through plasmonic nanopores.…”

“…71,72 Probing by such ‘needle-type’ SERS substrates may be particularly suitable for a microanalysis of the extracellular space, in cell cultures or even tissues, for sensing of neurotransmitters, 73 or metabolites such as glucose, 74 or ATP. 40…”