“…However, reasonable yields can be obtained via carefully controlled condensation reactions between propiolates and amines. , Additionally, there are other methods that afford propiolamides such as acylation reactions employing carbamoyl chlorides, ,, photocatalyzed decarboxylative ynonylation, dehydrogenative coupling of terminal alkynes with formamides, or palladium-catalyzed multicomponent reactions among alkynes, isonitriles, and carboxylates . More esoteric electron deficient alkynes such as ethynylsulfones are conveniently isolated from sulfonyl chlorides, , sulfonyl hydrazides, sulfinates, , or via multicomponent reactions, for example, photocatalyzed coupling of sulfur dioxide and alkynyl bromides. , While their use as a substrate in Michael reactions is comparatively rare next to other activated alkynes, they are still very reactive in reported examples , and this provides ample opportunity for further work. Propiolonitriles are also susceptible to 1,4-conjugate additions from heteronucleophiles, however, they are not as common in this context due to a lack of functional modularity.…”