Electrochemically nano-engineered titanium: Influence of dual micro-nanotopography of anisotropic nanopores on bioactivity and antimicrobial activity

Osteoimmune-modulating and BMP-2-eluting anodised 3D printed titanium for accelerated bone regeneration

“…These aspects of our work differentiate it from the previously conducted studies that have predominantly focused on flat Ti substrates. 15,20,21,28 This work concludes that the optimised surface topography in combination with controlled, sustained, and local release of bioactive forms of growth factors has potential to significantly improve osseointegration outcomes for patients implanted with custom 3D printed Ti implants in future.…”

“…Titanium nanotubes (TiNTs) are very well-characterised materials and various studies have investigated their interactions with immune cells and have shown their ability to modulate immune behaviour by carefully crafting surface features and chemistries. 15,[19][20][21] However, the majority of these studies have utilised a standard titanium material with smooth surface. With the rapid advent of 3D metal printing, customised Ti implants have become a reality.…”

Surface Modification and Functionalities for Titanium Dental Implants

“…Surface modification can optimize the micro/nanotopography and composition of the implant surface, which can effectively improve the roughness and hydrophilicity of the implant, facilitate the binding of osteoblasts with the implant, and promote osseointegration. On the other hand, modification of antibacterial components on the surface of Ti implants can effectively inhibit bacterial proliferation and avoid inflammation. − Appropriate surface modification techniques can effectively achieve the desired goals. In this Review, we systematically review the development of the latest surface modification techniques of Ti dental implants.…”

Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis

“…To further enhance its biomimetic properties, it is anticipated that a micro/nano topography, resembling the hierarchical structure of natural bone, is always developed on the surface of the titanium scaffold [ 9 , 10 ]. This multi-scale topography plays a crucial role in orchestrating distinct biological responses from osteoblasts [ 11 , 12 ]. Microstructures have been widely acknowledged for their ability to enhance cell adhesion, migration, and alignment during the initial osseointegration process.…”