Electrochemically oxidized multiwalled carbon nanotube/glassy carbon electrode as a probe for simultaneous determination of dopamine and doxorubicin in biological samples

Abstract

A facile and effective approach of fabricating oxidized multiwalled carbon nanotube/glassy carbon electrode (OMWCNT/GCE) is herein reported. The OMWCNT/GCE was prepared by electrochemical oxidation method in basic media (0.5 mol L(-1) NaOH solution) and used as a sensor for simultaneous determination of dopamine (DA) and doxorubicin (DOX). Scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry were used for characterization and performance study of the OMWCNT/GCE. The modified electrode exhibited good electrocatalytic properties toward the oxidation of DA and DOX. Peaks potential difference of 240 mV between DA and DOX was large enough to determine DA and DOX individually and simultaneously. Square wave voltammetry (SWV) was used for the simultaneous determination of DA and DOX in their binary mixture. Under the optimum conditions, the linear concentration dependences of SW peak current responses were observed for DA and DOX in the concentration ranges of 0.03-55 μmol L(-1) and 0.04-90 μmol L(-1), respectively. The detection limits (S/N = 3) were 8.5 × 10(-3) μmol L(-1), and 9.4 × 10(-3) μmol L(-1) for DA and DOX, respectively. The analytical utility of OMWCNT/GCE was also successfully demonstrated for the simultaneous determination of DA and DOX in human blood serum and urine samples. Graphical Abstract Fabrication of new oxidized multiwalled carbon nanotube/glassy carbon electrode for simultaneous determination of dopamine and doxorubicin.

Differential Pulse Voltammetry Determination of Ofloxacin in Human Serum and Urine Based on a Novel Tryptophan‐graphene Oxide‐carbon Nanotube Electrochemical Sensor

“…Carbon nanotube (CNT), another exciting carbon nanomaterial, is constituted of graphitic carbons which form one or several concentric tubules . During the past decades, CNT has attracted considerable attention for the task of electrochemical sensing because of its extraordinary electrical properties, large specific area, remarkable mechanical and unique architecture . The fabrication of GO‐CNT composite material has caused some concern because CNT can be acted as not only a spacer between GO nano‐sheets to prevent further aggregation but also an electrical nanowire which can connect the individual GO sheets and heighten the conductivity of the composite material .…”

Microelectrode Arrays Modified with Nafion/Nanoporous AuPt Nanoparticles for in vivo Detection of Dopamine

“…(12)(13)(14) Another important factor for developing in vivo DA electrochemical sensors is the sensitivity. Because the sensitivity of an electrochemical sensor is directly related to the electrode surface area and conductivity, a variety of nanostructured materials, such as metal oxide nanoparticles, (15)(16)(17) carbon nanotubes, (18,19) metal or bimetallic nanoparticles, (20)(21)(22)(23) graphene, (24)(25)(26) and nanocomposites, (27,28) have been proposed to modify the electrode.…”

Voltammetric sensing of dopamine in urine samples with electrochemically activated commercially available screen-printed carbon electrodes

“…[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] Glassy carbon electrodes (GCEs) were modified with sulfonated graphene 23 or with reduced graphene oxide. 24,25 There are reports on the use of GCE modified with various composite materials: a SiO 2 -coated graphene oxide and molecularly imprinted polymers, 26 nanocomposite with carbon nanotubes, [27][28][29] NiFe 2 O 4 magnetic nanoparticles decorated with multiwall carbon nanotubes, 30 with a carbon nanohorns/poly(glycine) composite, 31 with poly(o-methoxyaniline)-gold (POMA-Au) nanocomposite, 32 with a complex of gold nanoparticles and multiwall carbon nanotubes. 33 GCE modified with a combination of fullerene (C 60 )-functionalized carbon nanotubes and ionic liquid 1-butyl-3methylimidazolium tetrafluoroborate was used to determine several catecholamine's: nor epinephrine, isoprenaline and dopamine.…”