Electrochemically Recognizing Tryptophan Enantiomers based on Carbon Black/Poly-l-Cysteine Modified Electrode

Abstract

Construction of efficient and convenient sensors for recognition of chiral enantiomers is of much significance in the field of electrochemistry and life sciences. Herein, we designed an effective chiral interface for the successful identification of tryptophan (Trp) enantiomers by electrodepositing l-cysteine on the surface of glass carbon electrode modified with carbon black. The structure and morphology of the prepared sensor was characterized by scanning electron microscopy (SEM) and electrochemical methods. Compared with l-tryptophan (L-Trp), the sensor exhibits favorable chiral recognition towards D-tryptophan (D-Trp) with a separation coefficient of 2.50. Compared with existing studies on electrochemical chiral recognition of Trp enantiomers, our designed chiral platform boasts of a wider linear range (1.0-1400.0 μM) and lower limits of detection thus, 0.33 μM and 0.45 μM for L-Trp and D-Trp respectively. In addition, the proposed sensor has the capacity to recognize chiral molecules in Trp isomers mixture and the potential for the identification of other amino acids.

Highly sensitive determination of anesthetic drug benzocaine based on hydroxypropyl-β-cyclodextrin–carbon black nanohybrids

“…These outstanding superiorities of CB enable it to be a desirable alternative to carbon nanotubes and graphene, showing signicant application in electroanalysis. For example, Lounasvuori et al 26 used pure CB as an electrode material to electrochemically detect three phenols; Zhu et al 27 prepared a CB/poly-L-cysteine modied electrode to recognize electrochemically chiral tryptophan molecules. However, there is no report based on CB for BZC detection.…”

Simple, low-cost and sensitive electrochemical sensing of antineoplastic drug amethopterin based on a nanocarbon black modified electrode

“…Resulting from the high electro-conductivity and large specic surface area as well as excellent chemical/mechanical stabilities, the family of nanocarbon materials has received great attention in electrochemical sensing during the past decade. [19][20][21] However, carbon nanotubes, carbon nanohorns, graphene, and fullerenes recently have been of less interest owing to their tough synthetic procedures. Nanocarbon black (NCB), a carbonaceous material composed of amorphous and quasi-graphitic primary particles with the diameter range of 3.0-100.0 nm, is being preferred lately by many researchers.…”

Voltammetric sensor based on the copper (II) amino acid complex for the determination of tryptophan enantiomers

“…Ключевым элементом вольтамперометрического определения энантиомеров является иммобилизация хирального селектора на поверхность сенсора, которую осуществляют различными способами [18][19][20][21]. Для распознавания и определения энантиомеров Трп в последнее время широко применяются сенсоры из стеклоуглеродного электрода (СУЭ) с хиральными селекторами на основе композитов графена с хитозаном [22], хитозана с ДНК [23], композитов полиариленфталида (ПАФ) с циклодекстринами [24], а также композитов на основе многослойных углеродных нанотрубок с полидофамином и комплексов меди (II) [25], аминокислот и их производных [26][27]. Также имеются сведения о применении в качестве хиральных селекторов аминокислотных комплексов переходных металлов [28].…”