Electrochemiluminescence devices for point-of-care testing

Abstract

Point-of-care testing (POCT) is also known as near-patient or on-site testing. Because of its rapid, efficient, low-cost and convenient capability, POCT has been widely used in clinical diagnosis, infectious disease...

Plasmonic silver and gold nanoparticles: shape- and structure-modulated plasmonic functionality for point-of-caring sensing, bio-imaging and medical therapy

“…In some ECL sensors, a capture element (i.e., antibodies, aptamers, and enzymes with high specificity of the analyte) is incorporated on the working electrode's surface to selectively capture the target analyte of interest. 161 After the analyte is captured on the surface of working electrode, a sandwich structure is formed by the capture and detection elements and the reactants on the detection element are then excited to emit light when the voltage is applied to the electrode.…”

Disposable capillary-fill device for the determination of proteases incorporating elimination of light-shielding from the magnetic beads with cleavage of the electrogenerated chemiluminescence label-tagged peptide probe

“…Point-of-care testing (POCT), which involves real-time analysis near or at the site of patient specimen collection, has widespread applications in the fields of healthcare diagnostics and environmental monitoring 1,2 due to its excellent convenience, cost-effectiveness, specificity, accuracy, portability and low operation requirements. [3][4][5] Generally, emergent POCT systems use various biosensing methods with optical and electro-chemical readouts to provide quantitative results, 3,6 such as electrochemistry, 7 colorimetry, 8 electrogenerated chemiluminescence (ECL), 3,9,10 surface-enhanced Raman scattering, 11 fluorescence (FL), 12 etc. Among them, ECL is an ideal approach for POCT because of its advantages of high sensitivity at low concentrations, high spatiotemporal controllability, and the fact that it does not require an external light source.…”

“…Among them, ECL is an ideal approach for POCT because of its advantages of high sensitivity at low concentrations, high spatiotemporal controllability, and the fact that it does not require an external light source. 1,3,5,9 Proteases ( peptidase, proteinase) are a large family of proteolytic enzymes, such as prostate-specific antigen (PSA), trypsin, and matrix metalloproteinases, and are typical biomarkers for a variety of diseases, with examples including cancers, inflammation, and vascular diseases. [13][14][15] The development of sensitive and convenient approaches for the determination of proteases in disease diagnosis is important.…”

“…Among them, ECL is an ideal approach for POCT because of its advantages of high sensitivity at low concentrations, high spatiotemporal controllability, and the fact that it does not require an external light source. 1,3,5,9…”

A novel point-of-care diagnostic prototype system for the simultaneous electrochemiluminescent sensing of multiple traumatic brain injury biomarkers

“…In recent years however, various researchers have made significant efforts to develop and establish miniaturized ECL devices suitable for biomedical applications. Recent reviews by Bhaiyya et al 23 and Ying et al 24 give an overview of ECL-based systems/devices developed for POC settings. Even though it is evident that miniaturized ECL devices are gaining attention, there is still a need for miniaturized ECL platforms that will allow a simultaneous multi-analyte sensing.…”