Electrochemiluminescence resonance energy transfer between a Ru-ZnMOF self-enhanced luminophore and a double quencher ZnONF@PDA to detect NSE

Yang, Juan; Qin, Dongmiao; Wang, Na; Wu, Y.; Fang, Kanjun; Deng, Biyang

doi:10.1039/d3an01106b

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Generally, immunoassay methods for tumor markers require 1–2 h to incubate antibodies (Abs) or antigens (Ags) on the sensor . In practical applications, the Ag (or Ab) in the blood sample must be incubated in a constant-temperature chamber at 4 or 37 °C. , Therefore, the detection time of the actual sample is approximately 0.5 to 2 h. , Thus, on-site rapid and household tumor-marker detection meters have not yet been developed.…”

Section: Introductionmentioning

confidence: 99%

Wireless Gold/Boron–Nitrogen-Codoped Graphene-Based Antenna Immunosensor for the Rapid Detection of Neuron-Specific Enolase

Zu,

Xuan,

Zhang

et al. 2024

Anal. Chem.

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Tumor-marker immunosensors for rapid on-site detection have not yet been developed because of immunoreaction bottlenecks, such as shortening the reaction time and facilitating incubation. In this study, a gold−boron-nitrogen-codoped graphene (Au-BNG)-based immunosensor antenna was constructed for the rapid detection of neuron-specific enolase (NSE). A Au-BNG radiation electrode with dual functions of antibody protein fixation and signal transmission was developed for the first time. A radiation sample cell was constructed by embedding a radiation electrode into the groove of a poly(dimethylsiloxane) dielectric substrate. The constructed sense antenna achieves accurate detection of NSE with a range from 50 fg mL −1 to 40,000 pg mL −1 and a limit of detection of 10.99 fg mL −1 , demonstrating excellent selectivity, stability, and reliability. The tumor-marker detection meter can provide NSE detection results as rapidly as within 2 min by using the new strategy of the microwave self-incubation of tumor markers. This antenna immunosensor is suitable for rapid detection in outpatient clinics and can be developed into household tumor-marker detectors, which would be significant in the early detection, long-term monitoring, and efficacy evaluation of tumors.

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Section: Introductionmentioning

confidence: 99%

Wireless Gold/Boron–Nitrogen-Codoped Graphene-Based Antenna Immunosensor for the Rapid Detection of Neuron-Specific Enolase

Zu,

Xuan,

Zhang

et al. 2024

Anal. Chem.

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A comprehensive review of MOFs based on electrochemical biosensors as smart platforms in cancer biomarkers detection

Moharramnejad,

Karim,

Gharanli

et al. 2024

Microchemical Journal

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Electrochemiluminescence resonance energy transfer between a Ru-ZnMOF self-enhanced luminophore and a double quencher ZnONF@PDA to detect NSE

Abstract: The construction of advanced systems capable of accurately detecting neuron-specific enolase (NSE) is essential for rapidly diagnosing small-cell lung cancer. In this study, an electrochemiluminescence (ECL) resonance energy transfer immunosensor...

Cited by 2 publications

References 45 publications

Wireless Gold/Boron–Nitrogen-Codoped Graphene-Based Antenna Immunosensor for the Rapid Detection of Neuron-Specific Enolase

Wireless Gold/Boron–Nitrogen-Codoped Graphene-Based Antenna Immunosensor for the Rapid Detection of Neuron-Specific Enolase

A comprehensive review of MOFs based on electrochemical biosensors as smart platforms in cancer biomarkers detection

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