Electrochemistry and Detection of Dobutamine at Gold Nanoparticles Cobalt-Phthalocyanine Modified Carbon Paste Electrode

Abstract

Electrochemical sensor was fabricated for determination of dobutamine (DB) based on gold nanoparticles/cobaltphthalocyanine modified carbon paste electrode AuCoPcCPE. Two components in the composite structure contribute to the faradaic signal at the interface of the electrode: conduction of Au-nano-centers and charge mediation through cobalt-phthalocyanine moieties. The proposed sensor exhibited excellent performance for the determination of DB in human urine samples with satisfying recovery results. Low detection limit of 0.84 × 10 −7 mol L −1 in the linear dynamic range of 6.0 × 10 −6 mol L −1 to 2.0 × 10 −4 mol L −1 was obtained at the AuCoPcCPE sensor. It was possible to simultaneously and selectively determine DB in each of the following mixtures: DB/Morphine, DB/paracetamol using the AuCoPcCPE sensor. The proposed sensor exhibited high reproducibility, enhanced sensitivity, selectivity, and unique stability.

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

“…Another drug called dobutamine, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino] ethyl]-1,2-benzenediol, has been introduced as one of the most important inotropic synthetic catecholamine medicines with heavy β-adrenergic activities. Dobutamine is commonly utilized for treating cardiogenic shock and heart failure [8][9][10][11]. In fact, dobutamine contribute importantly to functions of the central nervous, hormonal, renal, and cardio-vascular systems.…”

Electrochemical sensing of dobutamine, paracetamol, amlodipine, and daclatasvir in serum based on thiourea SAMs over nano-gold particles–CNTs composite

“…DB improves blood flow, raises cardiac output, and relieves symptoms of coronary heart disease. [13][14][15][16][17][18][19][20][21][22] DB is usually administered via intravenous infusion because it has Chemistry Department, Faculty of Science, Cairo University, 12613, Giza, Egypt. E-mail: anada@sci.cu.edu.eg † Electronic supplementary information (ESI) available.…”

“…[13][14][15][25][26][27][28] Psychiatric disorders and neurological diseases are associated with abnormalities of DB levels in the brain. 19 Therefore, it is important to develop a sensitive approach to determine the concentrations of DB in biological fluids. Determination of DB was previously reported by different methods such as reverse phase high-performance liquid chromatography (RP-HPLC), 29 and spectrophotometric methods.…”

“…DB improves blood flow, raises cardiac output, and relieves symptoms of coronary heart disease. 13–22 DB is usually administered via intravenous infusion because it has small bioavailability when orally administered. 23 Usually, vasodilation caused by β 2 -receptors takes place after DB infusion which results in no significant increase in the systemic blood pressure or heart rate.…”

Heterostructures Based on Cobalt Phthalocyanine Films Decorated with Gold Nanoparticles for the Detection of Low Concentrations of Ammonia and Nitric Oxide

“…To date, Au-containing hybrid materials are already used as materials for electrochemical sensors detecting glucose and NO metabolites [ 46 , 47 , 48 ], while the possibility of using these heterostructures for the detection of N-containing gases has not yet been sufficiently studied. Wet chemical methods [ 49 , 50 , 51 ] are traditionally used to fabricate AuNPs on various surfaces. The latest reports have shown the advantages of using gas-phase methods for the deposition of metal layers and nanoparticles on the surface of organic semiconductors to create sensing layers with good sensor performance [ 34 , 52 , 53 ].…”